Results 161 to 170 of about 114,219 (358)
A putative ATPase mediates RNA transcription and capping in a dsRNA virus. [PDF]
, 2015 mRNA transcription in dsRNA viruses is a highly regulated process but the mechanism of this regulation is not known. Here, by nucleoside triphosphatase (NTPase) assay and comparisons of six high-resolution (2.9-3.1 Å) cryo-electron microscopy structures ...
Jiang, Jiansen +3 more
core +1 more source
The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis
Cancer Science, EarlyView.In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley +1 more source
Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance
Genome Biology, 2017 Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional modification catalyzed by the ADAR (adenosine deaminase that acts on RNA) enzymes, which are ubiquitously expressed among metazoans.
Hagit T. Porath +3 more
semanticscholar +1 more source
Utilization of Bacteriophage phi6 for the Production of High-Quality Double-Stranded RNA Molecules
VirusesDouble-stranded RNA (dsRNA) molecules are mediators of RNA interference (RNAi) in eukaryotic cells. RNAi is a conserved mechanism of post-transcriptional silencing of genes cognate to the sequences of the applied dsRNA.
Alesia A. Levanova, Minna M. Poranen
doaj +1 more source
BMC Evolutionary Biology, 2012 Background Double-stranded (ds) RNA fungal viruses are typically isometric single-shelled particles that are classified into three families, Totiviridae, Partitiviridae and Chrysoviridae, the members of which possess monopartite, bipartite and ...
Liu Huiquan +8 more
doaj +1 more source
Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects
Cell Proliferation, EarlyView.The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang +3 more
wiley +1 more source
International Journal of Molecular Sciences, 2018 RNA interference (RNAi) effects in insects are highly variable and may be largely dependent upon the stability of introduced double-stranded RNAs to digestion by nucleases.
M. Cao, J. Gatehouse, E. Fitches
semanticscholar +1 more source
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]
, 2013 Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M +4 more
core +1 more source
FishesThe South Korean aquaculture industry has incurred considerable production losses due to various infectious diseases. Artificially synthesized polyinosinic–polycytidylic acid (poly I:C), structurally similar to double-stranded RNA (dsRNA) and cytidine ...
Hee-Jae Choi +7 more
doaj +1 more source
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, EarlyView.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source