Results 171 to 180 of about 99,698 (261)

Repeated Episodes of GPP Induced by Respiratory Infections Are Mediated by Loss‐of‐Function IFIH1

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Generalized pustular psoriasis (GPP) is a severe and recurrent autoinflammatory disease that can be induced by a variety of factors. At present, its etiology and pathogenesis have not yet been fully elucidated. Upper respiratory tract infections are the main predisposing factor in children with GPP, and the MDA5 protein encoded by ...
Yaqin Liu   +5 more
wiley   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri   +5 more
wiley   +1 more source

Cellular uptake of extracellular dsRNA is tissue-dependent in insects. [PDF]

open access: yesBMC Biol
Shi X   +9 more
europepmc   +1 more source

RNAi-mediated knockdown of the poultry red mite cathepsin D-1 impacts haemoglobin digestion. [PDF]

open access: yesParasit Vectors
Chen W   +9 more
europepmc   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin   +9 more
wiley   +1 more source

Control Strategies of Plant Viruses Using Spray-Induced Gene Silencing. [PDF]

open access: yesPlant Pathol J
Choi SK   +4 more
europepmc   +1 more source

An RNA interference biopesticide reduces reproduction of the honey bee parasite Varroa destructor by down‐regulating embryo development pathways

open access: yesPest Management Science, Volume 82, Issue 3, Page 2694-2707, March 2026.
Varroa destructor mites exposed to dsRNA specific in sequence to a V. destructor calmodulin gene significantly effected gene expression of adult female mites sampled 5 days after entering a honey bee brood cell to reproduce. Significantly down‐regulated genes included Calmodulin and were associated with calcium ion binding and embryo developmental ...
Zoe E Smeele   +10 more
wiley   +1 more source

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