PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration [PDF]
Nature CommunicationsThe innate immune sensor PKR for double-stranded RNA (dsRNA) is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases.
Sadeem Ahmad +15 more
doaj +2 more sources
Diversity and Current Classification of dsRNA Bacteriophages
Viruses, 2023 Half a century has passed since the discovery of Pseudomonas phage phi6, the first enveloped dsRNA bacteriophage to be isolated. It remained the sole known dsRNA phage for a quarter of a century and the only recognised member of the Cystoviridae family until the year 2018.
Sari Mäntynen +2 more
openaire +4 more sources
A Reverse Genetics System for dsRNA Viruses [PDF]
Cell Host & Microbe, 2007 The advent of a new reverse genetics system for reoviruses, described in this issue of Cell Host & Microbe by Kobayashi et al., opens new horizons of investigation into the molecular mechanisms governing dsRNA virus replication and pathogenesis. The elegant approach for recombinant reovirus recovery from a set of plasmid DNAs provides a template for ...
Ralph S. Baric, Amy C. Sims
openaire +5 more sources
Functional Characterization and Heterogeneity Analysis of Ribosomal Proteins in Mouse Preimplantation Embryos. [PDF]
FASEB JWe selected and investigated six ribosomal proteins in the early mouse embryo. Knocking down these ribosomal proteins generally had inhibitory effects on the morula‐to‐blastocyst transition, but the details and degree of these effects varied. This provides a new example of ribosome heterogeneity in preimplantation embryos.
Lee SJ +5 more
europepmc +2 more sources
Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon [PDF]
Communications BiologyIn vertebrates and plants, dsRNA plays crucial roles as PAMP and as a mediator of RNAi. How higher fungi respond to dsRNA is not known. We demonstrate that Magnaporthe oryzae (Mo), a globally significant crop pathogen, internalizes dsRNA across a broad ...
Ying Zheng +10 more
doaj +2 more sources
Application of Double-stranded RNA (dsRNA) Produced by E. coli HT115 (DE3) and Vector L4440 in Reverse Genetics Studies in Insects [PDF]
Journal of Genetic Resources, 2023 RNA interference is a cellular process for regulating gene expression by double-stranded RNA (dsRNA). In the past two decades, this cellular process has been used as a tool for the temporary knockdown of gene expression to study gene function in reverse ...
Roohollah Abbasi
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Double-stranded RNAs are promising adjuvants for enhancing immunogenicity of vaccines
Журнал микробиологии, эпидемиологии и иммунобиологии, 2023 Background. The most effective way to prevent infectious diseases is vaccination. Adjuvants contribute to the optimization of the immune response of vaccines.
Olga N. Kaplina +3 more
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cGAS/STING-Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B. [PDF]
FASEB JMechanism of HEXIM1 regulation of Type I Interferon. ABSTRACT Studies support the role of hexamethylene bis‐acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor suppressor. We previously reported that the histone demethylase, KDM5B, inhibits the expression of HEXIM1, and KDM5B inhibitors (KDM5Bi) upregulate HEXIM1 expression. As a consequence, KDM5Bi
Montano MM, Yeh IJ, Ketchart W.
europepmc +2 more sources
Artificial nanovesicles for dsRNA delivery in spray‐induced gene silencing for crop protection
Plant Biotechnology Journal, 2023 Summary Spray‐induced gene silencing (SIGS) is an innovative and eco‐friendly technology where topical application of pathogen gene‐targeting RNAs to plant material can enable disease control.
Lulu Qiao +6 more
semanticscholar +1 more source
Biological control of pathogenic fungi: Can mycoviruses play an important role? [PDF]
Journal of Central European Agriculture, 2022 In the past few years, huge economic and environmental losses have resulted by fungal pathogens in agriculture and food production worldwide. Fungal toxins also pose a threat for food production and animal health.
Tomáš Tonka +2 more
doaj +1 more source