Results 11 to 20 of about 99,698 (261)

RNAi‐Based Pesticides: Genetic Innovations for Sustainable Crop Protection and One Health [PDF]

Advanced Genetics, Volume 7, Issue 1, March 2026.
RNAi‐based pesticides offer precise, gene‐specific pest control using dsRNA to silence essential insect genes. Advanced delivery systems (nanoparticles, SIGS, HIGS) and multi‐omics‐driven target discovery enable effective, scalable, and environmentally safe crop protection, supporting biodiversity, human health, and One Health‐aligned sustainable ...
Jisheng Liu, Guy Smagghe
wiley   +2 more sources

Universal and quantitative detection of double-stranded RNAs as a signature of pan-virus infections using a luciferase-based biosensor [PDF]

Journal of Biological Engineering
Background Infections with various RNA viruses and certain DNA viruses may produce double-stranded RNA (dsRNA) during replication, which trigger host innate immune responses.
Michihito Sasaki, Eri Fujii, Satoko Sasaki, Takuma Ariizumi, Kei Konishi, Akihiko Sato, William W. Hall, Hirofumi Sawa, Yasuko Orba   +8 more
doaj   +2 more sources

Evaluating the potential of RNA interference for control of striped cucumber beetle, Acalymma vittatum (Fabricius) (Coleoptera: Chrysomelidae) [PDF]

Pest Management Science, Volume 82, Issue 4, Page 3591-3602, April 2026.
SCB has a robust RNAi response to injected dsRNA, but oral RNAi is less efficient. Nucleases do not appear to be responsible for the discrepancy, suggesting other factors are involved. Abstract BACKGROUND The striped cucumber beetle (SCB) is a serious pest of cucurbit crops, causing damage both by feeding on plants and by vectoring plant diseases ...
Emine Kaplanoglu, Félix Longpré, Cam Donly   +2 more
wiley   +2 more sources

Inhibiting ADAR1‐Mediated Excessive Epigenetic A‐to‐I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma [PDF]

MedComm, Volume 7, Issue 3, March 2026.
This study investigated the potential of inhibiting ADAR1 which catalyzed excessive A‐to‐I RNA editing as a therapeutic strategy to augment the effectiveness of immunotherapy in LUAD. Mouse models demonstrated that inhibiting ADAR1 in tumor cells significantly improved the immune microenvironment by increasing PD‐L1 expression and CD8+ T‐cell ...
Sihui Wang, Sufei Zheng, Chengming Liu, Chaoqi Zhang, Xinfeng Wang, Zhanyu Wang, Yan Wang, Xiaoli Feng, Qi Xue, Nan Sun, Jie He   +10 more
wiley   +2 more sources

Double-stranded RNA antiviral signature in early multiple sclerosis [PDF]

Frontiers in Microbiology
IntroductionViruses, particularly Epstein–Barr virus (EBV), are strongly implicated in multiple sclerosis (MS) pathogenesis, yet reliable biomarkers of active viral replication remain limited.
Vasileios Gouzouasis, Vasileios Gouzouasis, Ioannis Sarrigeorgiou, Margaritis Tsifintaris, Nikos Markoglou, Urania Georgopoulou, Peggy Lymberi, Maria Anagnostouli, Lesley Probert, Antonis Giannakakis, Antonis Giannakakis   +10 more
doaj   +2 more sources

Psychrophilic phage VSW-3 RNA polymerase reduces both terminal and full-length dsRNA byproducts in in vitro transcription

RNA Biology, 2022
RNA research and applications are underpinned by in vitro transcription (IVT), but RNA impurities resulting from the enzymatic reagents severely impede downstream applications. To improve the stability and purity of synthesized RNA, we have characterized
Heng Xia, Bingbing Yu, Yixin Jiang, Rui Cheng, Xueling Lu, Hui Wu, Bin Zhu   +6 more
doaj   +1 more source

Symptomatic, widespread, and inconspicuous: new detection of tomato fruit blotch virus

Phytopathologia Mediterranea, 2023
Tomato production is an important part of the Swiss vegetable production with most tomato crops grown in greenhouses. Tomato plants are vulnerable to diseases caused by viruses, which can have significant impacts on crop production.
Arnaud G. BLOUIN, Nathalie DUBUIS, Justine BRODARD, Laure APOTHÉLOZ-PERRET-GENTIL, Denise ALTENBACH, Olivier SCHUMPP   +5 more
doaj   +1 more source

Transmission of HetRV6 ve HetPV13 Mycoviruses to Heterobasidion abietinum and Heterobasidion annosum isolates

Turkish Journal of Forestry, 2020
Heterobasidion annosum Fr. Bref. sensu lato is a highly destructive disease factor that causes root and root collar rot in the temperate zone of the Northern Hemisphere, especially in coniferous tree species. In the control of Heterobasidion species, the
Ayse Gülden Aday Kaya, Tuğba Doğmuş
doaj   +1 more source

Antiviral Activity of Double-Stranded Ribonucleic Acid and Interferon Alpha Composition in the Model of Experimental Influenza Infection of Mice

Антибиотики и Химиотерапия, 2023
High variability of influenza viruses requires the development of agents for nonspecific resistance stimulation, along with the development of new drugs for prevention and treatment.
S. G. Gamaley, М. O. Skarnovich, E. V. Makarevich, О. Yu. Mazurkov, L. N. Shishkina, О. S. Ivanova, G. M. Levagina, Е. D. Danilenko   +7 more
doaj   +1 more source

Studying the effect of double-stranded RNA upon activity of mouse splenocytes using flow cytometry

Медицинская иммунология, 2023
Ribonucleic acids (RNA), in particular, double-stranded RNAs, due to their ability to modulate innate immune responses, are of undoubted interest in view of their usage as vaccine adjuvants.
E. S. Tsyplenkova, E. A. Vyazovaya, E. D. Danilenko   +2 more
doaj   +1 more source