Results 21 to 30 of about 114,219 (358)
Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA
bioRxiv, 2022 Proper defense against microbial infection depends on the controlled activation of the immune system. This is particularly important for the RIG-I-like receptors (RLRs), which recognize viral dsRNA and initiate antiviral innate immune responses with the ...
Max Paget +11 more
semanticscholar +1 more source
Инфекция и иммунитет, 2021 A search for new targeted therapeutic strategies based on examining immunopathogenetic mechanisms for emerging co-infections is relevant and may further contribute not only to optimizing choice of immunotropic drugs, but also to achieving positive ...
I. V. Nesterova +6 more
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A prenylated dsRNA sensor protects against severe COVID-19
Science, 2021 Description The bat connection The heterogeneity of COVID-19 makes it challenging to predict the course of infection in an individual. Upon virus infection, interferons (IFNs) generate the initial signals for cellular defenses.
Arthur Wickenhagen +47 more
semanticscholar +1 more source
RNAi-based pest control: Production, application and the fate of dsRNA
Frontiers in Bioengineering and Biotechnology, 2022 The limitations of conventional pesticides have raised the demand for innovative and sustainable solutions for plant protection. RNA Interference (RNAi) triggered by dsRNA has evolved as a promising strategy to control insects in a species-specific ...
Li He, Yanna Huang, Xueming Tang
semanticscholar +1 more source
Advances in nanocarriers to improve the stability of dsRNA in the environment
Frontiers in Bioengineering and Biotechnology, 2022 RNAi technology, known as a revolutionary technology in the history of pesticides, has been identified as a very promising novel approach for crop protection, which is of great significance for achieving the sustainable agricultural development of the ...
Wenling Yang +4 more
semanticscholar +1 more source
The Functional Mechanisms of Toll-Like Receptor 3 and Its Implications in Digestive System Tumors
Frontiers in Bioscience-Landmark, 2023 Toll-like receptor 3 (TLR3) is a prominent member of the Toll-like receptor (TLR) family and has the ability to recognize and bind intracellular double-stranded RNA (dsRNA).
Bin Han +7 more
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Strategies for the production of dsRNA biocontrols as alternatives to chemical pesticides
Frontiers in Bioengineering and Biotechnology, 2022 Current crop pest control strategies rely on insecticidal and fungicidal sprays, plant genetic resistance, transgenes and agricultural practices.
James Hough +5 more
semanticscholar +1 more source
Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
Nature, 2022 Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA-silencing mechanism in many eukaryotes1,2. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided by its cofactor Loquacious-PD (Loqs-PD), has an ...
Shichen Su +9 more
semanticscholar +1 more source
Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA
RNA Biology, 2021 RNAi is a potent technique for the knockdown of target genes. However, its potential off-target effects limit the widespread applications in both reverse genetic analysis and genetic manipulation.
Jiasheng Chen +7 more
semanticscholar +1 more source
Turkish Journal of Forestry, 2020 Heterobasidion annosum Fr. Bref. sensu lato is a highly destructive disease factor that causes root and root collar rot in the temperate zone of the Northern Hemisphere, especially in coniferous tree species. In the control of Heterobasidion species, the
Ayse Gülden Aday Kaya, Tuğba Doğmuş
doaj +1 more source