Results 21 to 30 of about 74,293 (296)
Cold Spring Harbor Perspectives in Biology, 2019 Long double-stranded RNAs (dsRNAs) are abundantly expressed in animals, in which they frequently occur in introns and 3' untranslated regions of mRNAs. Functions of long, cellular dsRNAs are poorly understood, although deficiencies in adenosine deaminases that act on RNA, or ADARs, promote their recognition as viral dsRNA and an aberrant immune ...
Daniel P, Reich, Brenda L, Bass
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Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA
RNA Biology, 2021 RNAi is a potent technique for the knockdown of target genes. However, its potential off-target effects limit the widespread applications in both reverse genetic analysis and genetic manipulation.
Jiasheng Chen +7 more
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RNA Biology, 2022 RNA research and applications are underpinned by in vitro transcription (IVT), but RNA impurities resulting from the enzymatic reagents severely impede downstream applications. To improve the stability and purity of synthesized RNA, we have characterized
Heng Xia +6 more
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Advances in nanocarriers to improve the stability of dsRNA in the environment
Frontiers in Bioengineering and Biotechnology, 2022 RNAi technology, known as a revolutionary technology in the history of pesticides, has been identified as a very promising novel approach for crop protection, which is of great significance for achieving the sustainable agricultural development of the ...
Wenling Yang +4 more
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Symptomatic, widespread, and inconspicuous: new detection of tomato fruit blotch virus
Phytopathologia Mediterranea, 2023 Tomato production is an important part of the Swiss vegetable production with most tomato crops grown in greenhouses. Tomato plants are vulnerable to diseases caused by viruses, which can have significant impacts on crop production.
Arnaud G. BLOUIN +5 more
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dsRNA-induced condensation of antiviral proteins modulates PKR activity
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance The presence of dsRNA in the cytosol is a marker of infection and elicits an immune response. One aspect of this immune response is the activation of the eIF2α kinase PKR, which results in translational reprogramming and stress granule ...
Giulia A. Corbet +4 more
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Turkish Journal of Forestry, 2020 Heterobasidion annosum Fr. Bref. sensu lato is a highly destructive disease factor that causes root and root collar rot in the temperate zone of the Northern Hemisphere, especially in coniferous tree species. In the control of Heterobasidion species, the
Ayse Gülden Aday Kaya, Tuğba Doğmuş
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Strategies for the production of dsRNA biocontrols as alternatives to chemical pesticides
Frontiers in Bioengineering and Biotechnology, 2022 Current crop pest control strategies rely on insecticidal and fungicidal sprays, plant genetic resistance, transgenes and agricultural practices.
James Hough +5 more
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Антибиотики и Химиотерапия, 2023 High variability of influenza viruses requires the development of agents for nonspecific resistance stimulation, along with the development of new drugs for prevention and treatment.
S. G. Gamaley +7 more
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Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
Nature, 2022 Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA-silencing mechanism in many eukaryotes1,2. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided by its cofactor Loquacious-PD (Loqs-PD), has an ...
Shichen Su +9 more
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