Results 51 to 60 of about 114,219 (358)

An Investigation of Innate Immune Response of Human Blood Macrophage to Sense and Antisense dsRNA

Trends in Peptide and Protein Sciences, 2016
Silencing of gene expression by siRNA (small interfering RNA) is a powerful approach used to study the genetic analysis and functional roles of mammalian genes.
Nasrin Mohajeri, Zarrin Sharifnia, Mojgan Bandehpour, Fatemeh Yarian, Amaneh Koochaki, Nariman Mosaffa, Kazem Parivar, Bahram Kazemi   +7 more
doaj   +1 more source

Is there any sense in antisense editing? [PDF]

Trends in Genetics 21, 544-7 (2005), 2005
A number of recent studies have hypothesized that sense-antisense RNA transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. Here we studied human and mouse genomic antisense regions, and found that the editing level in these areas is negligible.
arxiv   +1 more source

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, Amanda, Bridgen, Anne, Elliott, Richard M, Fazakerley, John K, Streitenfeld, Hein, Weber, Friedemann   +5 more
core   +3 more sources

Double-stranded RNA elements associated with the MVX disease of Agaricus bisporus [PDF]

, 2003
Double-stranded RNA (dsRNA) has been isolated from Agaricus bisporus fruit bodies exhibiting a wide range of disease symptoms. The symptoms which occurred singularly or in combination included; bare cropping areas on commercial beds (primordia disruption)
Adie, Bruce A. T., Challen, Michael P., Gaze, R. H., Grogan, Helen M., Millis, P. R. (Peter R.)   +4 more
core   +1 more source

RNAi-mediated gene silencing in Rhynchophorus ferrugineus (Oliver) (Coleoptera: Curculionidae)

Open Life Sciences, 2017
RNA interference (RNAi) is a powerful strategy for gene function analysis, and it is also widely studied in view of a promising use in pest control. The red palm weevil, Rhynchophorus ferrugineus (Oliver) (Coleoptera: Curculionidae), is one of the most ...
Laudani Francesca, Strano Cinzia P., Edwards Martin G., Malacrinò Antonino, Campolo Orlando, Abd El Halim Hesham M., Gatehouse Angharad M. R., Palmeri Vincenzo   +7 more
doaj   +1 more source

Gene silencing in tick cell lines using small interfering or long double-stranded RNA [PDF]

, 2012
Gene silencing by RNA interference (RNAi) is an important research tool in many areas of biology. To effectively harness the power of this technique in order to explore tick functional genomics and tick-microorganism interactions, optimised parameters ...
A-C Barnard, AA Latif, AE Lew-Tabor, Alain Kohl, AM Nijhof, AM Nijhof, CL Donald, DE Brackney, EF Blouin, EM Morazzani, Esther Schnettler, F Jongejan, G Attarzadeh-Yazdi, G Barry, Gerald Barry, GJ Hannon, I Sifuentes-Romero, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, JC Clemens, JC Scott, JE George, JH Pedra, John K. Fazakerley, K Kiiver, KM Kocan, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Song, Lesley Bell-Sakyi, MGR Varma, P Liljestrom, P Lingor, P Willadsen, Pilar Alberdi, R Fragkoudis, R Fragkoudis, RA Zambon, S Bivalkar-Mehla, S Garcia, S Garcia, S Kurscheid, S Narasimhan, Sabine Weisheit, SM Hammond, SW Ding, TJ Kurtti, TJ Kurtti, UG Munderloh, V Nene, V Shkap, Z Zivkovic, Z Zivkovic   +57 more
core   +4 more sources

Quelling an innate response to dsRNA

Oncotarget, 2015
The interferon inducible oligoadenylate synthetase (OAS)/RNase L pathway is an innate defense against invading viral pathogens that is linked to cell survival [reviewed in 1]. OAS family proteins are pattern recognition receptors that recognize double-stranded RNA (dsRNA), a pathogen-associated molecular pattern.
Kristen M. Ogden, B. V. Venkataram Prasad   +1 more
openaire   +3 more sources

Injection of dsRNA into Female A. aegypti Mosquitos [PDF]

Journal of Visualized Experiments, 2007
Reverse genetic approaches have proven extremely useful for determining which genes underly resistance to vector pathogens in mosquitoes. This video protocol illustrates a method used by the James lab to inject dsRNA into female A. aegypti mosquitoes, which harbor the dengue virus.
Brian Luna, Anthony A. James, Jennifer Juhn   +2 more
openaire   +3 more sources

Force-dependent elasticity of nucleic acids [PDF]

arXiv, 2022
The functioning of double-stranded (ds) nucleic acids (NAs) in cellular processes is strongly mediated by their elastic response. These processes involve proteins that interact with dsDNA or dsRNA and distort their structures. The perturbation of the elasticity of NAs arising from these deformations is not properly considered by most theoretical ...
arxiv  

Suppression of nitric oxide (NO)-dependent behavior by double-stranded RNA-mediated silencing of a neuronal NO synthase gene [PDF]

, 2002
We have used double-stranded RNA (dsRNA)-mediated RNA interference (RNAi) to disrupt neuronal nitric oxide (NO) synthase (nNOS) gene function in the snail Lymnaea stagnalis and have detected a specific behavioral phenotype.
Benjamin, Paul R, Kemenes, György, Kemenes, Ildikó, Korneev, Sergei A, Korneeva, Elena I, O’Shea, Michael, Staras, Kevin, Straub, Volko   +7 more
core   +2 more sources