Results 21 to 30 of about 4,333 (201)
Emerging Microbes and Infections, 2023 Intestinal epithelial cell interactions with enteric pathogens have been incompletely elucidated owing to the lack of model systems that recapitulate the cellular diversity, architecture and functionality of the intestine.
Miaomiao Yan +8 more
doaj +1 more source
Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro
Frontiers in Microbiology, 2020 Porcine deltacoronavirus (PDCoV) is a novel emerging enteric coronavirus found in pigs. Intestinal enteroids, which partially recreate the structure and function of intestinal villi-crypts, have many physiological similarities to the intestinal tissues ...
Hao Luo +9 more
doaj +1 more source
Gastro Hep Advances, 2023 Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier.
Tatiana A. Karakasheva +17 more
doaj +1 more source
The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]
, 2020 The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita +9 more
core +3 more sources
Molecular Metabolism, 2021 Objective: The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood.
Nesrin M. Hasan +10 more
doaj +1 more source
Intestinal organoid/enteroid-based models for Cryptosporidium
Current Opinion in Microbiology, 2020 Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations.
Bhalchandra, Seema +2 more
openaire +2 more sources
Dasabuvir inhibits human norovirus infection in human intestinal enteroids [PDF]
mSphere, 2021 AbstractHuman noroviruses (HuNoVs) are acute viral gastroenteritis pathogens that affect all age groups, yet no approved vaccines and drugs to treat HuNoV infection are available. In this study, with a human intestinal enteroid (HIE) culture system where HuNoVs are able to replicate reproducibly, we screened an antiviral compound library to identify ...
Tsuyoshi Hayashi +8 more
openaire +3 more sources
The Journal of Clinical Investigation, 2023 Microvillus inclusion disease (MVID), caused by loss-of-function mutations in the motor protein myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea, malabsorption, and acid/base instability, requiring intensive parenteral support ...
Meri Kalashyan +12 more
doaj +1 more source
From 3D Organoids back to 2D Enteroids [PDF]
Developmental Cell, 2018 In this issue of Developmental Cell, Thorne et al. (2018) describe a simple, scalable method to culture 2D enteroid monolayers that surprisingly recapitulates many of the features of 3D organoid cultures and in vivo intestinal tissue and can be used for high-throughput microscopy-based experiments.
Jonathan, Braverman, Ömer H, Yilmaz
openaire +2 more sources
Di-san junyi daxue xuebao, 2020 Objective To compare the potentiality and characteristics of different intestinal epithelial cell (IEC) lines to grow into enteroids when cultured in 3D system in order to provide experimental basis for the cultivation of enteroids by IECs. Methods Three
OU Jing, XU Zhenni, LIU Dengqun
doaj +1 more source