Results 41 to 50 of about 4,333 (201)

Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. [PDF]

, 2019
Adult intestinal epithelial stem cells are a promising resource for treatment of intestinal epithelial disorders that cause intestinal failure and for intestinal tissue engineering.
Cho, Yonghoon, Dunn, James CY, Hong, Sung Noh, Khalil, Hassan A, Lewis, Michael S, Martin, Martin G, Rouch, Joshua D, Scott, Andrew, Stelzner, Matthias G, Wang, Jiafang   +9 more
core   +2 more sources

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis [PDF]

Journal of Visualized Experiments, 2019
Necrotizing enterocolitis (NEC) is a devastating disease of newborn infants. It is characterized by multiple pathophysiologic alterations in the human intestinal epithelium, leading to increased intestinal permeability, impaired restitution, and increased cell death.
Guillermo J, Ares, Christie, Buonpane, Carrie, Yuan, Douglas, Wood, Catherine J, Hunter   +4 more
openaire   +2 more sources

Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals

Frontiers in Immunology, 2021
Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system has been extensively studied, its intrinsic role in ...
Stamatia Papoutsopoulou, Stamatia Papoutsopoulou, Liam Pollock, Catherine Walker, William Tench, Sakim Shakh Samad, François Bergey, Luca Lenzi, Raheleh Sheibani-Tezerji, Phillip Rosenstiel, Mohammad Tauqeer Alam, Mohammad Tauqeer Alam, Vitor A. P. Martins Dos Santos, Vitor A. P. Martins Dos Santos, Werner Müller, Barry J. Campbell   +15 more
doaj   +1 more source

Interferon-lambda: A potent regulator of intestinal viral infections [PDF]

, 2017
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core   +3 more sources

Production of tissue-engineered intestine from expanded enteroids [PDF]

Journal of Surgical Research, 2016
Short bowel syndrome is a life-threatening condition with few solutions. Tissue-engineered intestine (TEI) is a potential treatment, but donor intestine is a limiting factor. Expanded epithelial surrogates termed enteroids may serve as a potential donor source.To produce TEI from enteroids, crypts were harvested from mice and enteroid cultures ...
Barrett P. Cromeens, Yanchun Liu, Johnathan Stathopoulos, Yijie Wang, Jed Johnson, Gail E. Besner   +5 more
openaire   +2 more sources

Fenofibrate reduces glucose-induced barrier dysfunction in feline enteroids

Scientific Reports, 2023
AbstractDiabetes mellitus (DM) is a common chronic metabolic disease in humans and household cats that is characterized by persistent hyperglycemia. DM is associated with dysfunction of the intestinal barrier. This barrier is comprised of an epithelial monolayer that contains a network of tight junctions that adjoin cells and regulate paracellular ...
Crawford, Charles, Beltran, Aeelin, Castillo, Diego, Matloob, Muhammad, Uehara, Mimoli, Quilici, Mary, Cervantes, Veronica, Kol, Amir   +7 more
openaire   +5 more sources

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Frontiers in Cellular and Infection Microbiology, 2021
Human parechovirus (PeV-A), one of the species within the Picornaviridae family, is known to cause disease in humans. The most commonly detected genotypes are PeV-A1, associated with mild gastrointestinal disease in young children, and PeV-A3, linked to ...
Inés García-Rodríguez, Inés García-Rodríguez, Hetty van Eijk, Gerrit Koen, Dasja Pajkrt, Dasja Pajkrt, Adithya Sridhar, Adithya Sridhar, Katja C. Wolthers   +8 more
doaj   +1 more source

Enteroids to Study Pediatric Intestinal Drug Transport. [PDF]

Mol Pharm
Intestinal maturational changes after birth affect the pharmacokinetics (PK) of drugs, having major implications for drug safety and efficacy. However, little is known about ontogeny-related PK patterns in the intestine. To explore the accuracy of human enteroid monolayers for studying drug transport in the pediatric intestine, we compared the drug ...
Streekstra EJ, Keuper-Navis M, van den Heuvel JJMW, van den Broek P, Stommel MWJ, de Boode W, Botden S, Bervoets S, O'Gorman L, Greupink R, Russel FGM, van de Steeg E, de Wildt SN.   +12 more
europepmc   +6 more sources

Proteomic Profiling of Enteroid Cultures Skewed Towards Development of Specific Epithelial Lineages [PDF]

, 2018
Recently, three‐dimensional small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic ...
Aoki-Yoshida, Barker, Farin, Finkbeiner, Forbester, Foureau, Gregorieff, Grootjans, Kaser, Komiya, McDole, Menendez, Patel, Peeters, Pelaseyed, Peterson, Pin, Pinto, Rodriguez-Pineiro, Salzman, Sato, Schweinlin, Specian, Uhlen, Wilson, Yin, Yin, Zhang, Zhang   +28 more
core   +5 more sources

Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model [PDF]

Infection and Immunity, 2019
The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis.
Ranganathan, Sridevi, Doucet, Michele, Grassel, Christen L., Delaine-Elias, BreOnna, Zachos, Nicholas C., Barry, Eileen M.   +5 more
openaire   +2 more sources