Results 51 to 60 of about 4,333 (201)

Human organoids are superior to cell culture models for intestinal barrier research

Frontiers in Cell and Developmental Biology, 2023
Loss of intestinal epithelial barrier function is a hallmark in digestive tract inflammation. The detailed mechanisms remain unclear due to the lack of suitable cell-based models in barrier research.
Catherine Kollmann, Hannah Buerkert, Michael Meir, Konstantin Richter, Kai Kretzschmar, Sven Flemming, Matthias Kelm, Christoph-Thomas Germer, Christoph Otto, Natalie Burkard, Nicolas Schlegel   +10 more
doaj   +1 more source

Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]

, 2013
Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D, Falk, Gary W, Hartman, Kira G, Lynch, John P, Martín, Martín G, Rustgi, Anil K, Yu, Jian   +6 more
core   +2 more sources

Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine. [PDF]

, 2020
The objective of the study was to identify the mechanism of action for a radiation mitigator of the gastrointestinal (GI) acute radiation syndrome (ARS), identified in an unbiased high-throughput screen.
Alli, Claudia, Bhat, Kruttika, Cheng, Fei, Duhachek-Muggy, Sara, Eghbali, Mansoureh, He, Ling, Medina, Paul, Muthukrishnan, Sree Deepthi, Pajonk, Frank, Ruffenach, Gregoire, Saki, Mohammad, Vlashi, Erina   +11 more
core   +1 more source

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions [PDF]

, 2017
Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries.
Begum, Yasmin Ara, Ciorba, Matthew A, Fleckenstein, James M, Hultgren, Scott J, Kuhlman, F. Matthew, Qadri, Firdausi, Rashu, Rasheduzzaman, Sheikh, Alaullah   +7 more
core   +3 more sources

Human Intestinal Organoids: Promise and Challenge

Frontiers in Cell and Developmental Biology, 2022
The study of human intestinal biology in healthy and diseased conditions has always been challenging. Primary obstacles have included limited tissue accessibility, inadequate in vitro maintenance and ethical constrains.
Jasin Taelman, Jasin Taelman, Mònica Diaz, Mònica Diaz, Jordi Guiu, Jordi Guiu   +5 more
doaj   +1 more source

WRN conditioned media is sufficient for in vitro propagation of intestinal organoids from large farm and small companion animals

Biology Open, 2017
Recent years have seen significant developments in the ability to continuously propagate organoids derived from intestinal crypts. These advancements have been applied to mouse and human samples providing models for gastrointestinal tissue development ...
Robin H. Powell, Michael S. Behnke
doaj   +1 more source

Modeling age‐dependent developmental changes in the expression of genes involved in citrulline synthesis using pig enteroids

Physiological Reports, 2020
Background Age‐dependent changes in the intestinal gene expression of enzymes involved in the metabolism of citrulline and arginine are well characterized.
Mahmoud A. Mohammad, Inka C. Didelija, Barbara Stoll, Douglas G. Burrin, Juan C. Marini   +4 more
doaj   +1 more source

Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis

Antioxidants, 2023
Necrotizing enterocolitis (NEC) is a neonatal intestinal disease associated with oxidative stress. The targets of peroxidation and the role of the innate intestinal epithelial antioxidant defense system are ill-defined.
Alena Golubkova, Tyler Leiva, Katherine Snyder, Camille Schlegel, Sarah M. Bonvicino, Martin-Paul Agbaga, Richard S. Brush, Jason M. Hansen, Peter F. Vitiello, Catherine J. Hunter   +9 more
doaj   +1 more source

The zinc finger transcription factor PLAGL2 enhances stem cell fate and activates expression of ASCL2 in intestinal epithelial cells [PDF]

, 2010
O encaminhamento de textos originais para submissão seguem algumas orientações básicas, levando em conta, inicialmente, que devem ser inéditos e que serão submetidos à aprovação de avaliadores especialistas nos temas tratados.
Strubberg, Ashlee M, Veronese Paniagua, Daniel A, Zhao, Tingting, Dublin, Leeran, Pritchard, Thomas, Bayguinov, Peter O, Fitzpatrick, James A.J., Madison, Blair B   +7 more
core   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source