Results 71 to 80 of about 4,333 (201)
The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]
, 2018 Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
core +2 more sources
Immune and Immune‐Integrated Organoids as NextGeneration Platforms for Disease Modeling
MedComm, Volume 6, Issue 12, December 2025.This graphical abstract outlines the sources and methods for integrating immune cells into organoids. Immune cells can be derived from peripheral blood, tissues, or differentiated from human‐induced pluripotent stem cells. The immune cells are incorporated into the organoid by using coculture techniques, direct injection, as well as scaffolds and air ...
Kimiya Rashidan +5 more
wiley +1 more source
The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair [PDF]
, 2015 In this study we characterized the effects of radiation injury on the expression and function of the autotaxin (ATX)-LPA2 GPCR axis. In IEC-6 crypt cells and jejunum enteroids quantitative RT-PCR showed a time- and dose-dependent upregulation of lpa2 in ...
Balazs, Louisa +15 more
core +1 more source
Generation of Intestinal and Colonic Organoids Derived From Human Pluripotent Stem Cells
Biology of the Cell, Volume 117, Issue 12, December 2025.Human pluripotent stem cells can be guided through a stepwise differentiation process to produce self‐organizing intestinal and colonic organoids. The resulting organoids recapitulate fetal‐stage epithelial and mesenchymal organization, offering a powerful model to explore human gastrointestinal development and its disorders.
Lola Bonneau +7 more
wiley +1 more source
Gut Microbes, 2020 Antibiotic resistance is one of the world’s greatest public health challenges and adjunct probiotic therapies are strategies that could lessen this burden.
Melinda A. Engevik +10 more
doaj +1 more source
Organoids, organs-on-chips and other systems, and microbiota [PDF]
, 2017 The human gut microbiome is considered an organ in its entirety and has been the subject of extensive research due to its role in physiology, metabolism, digestion, and immune regulation.
Evans, Samantha +2 more
core +2 more sources
Reviews in Medical Virology, Volume 35, Issue 6, November 2025.ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency, characterised by impaired antibody production, immune dysregulation, and a broad spectrum of clinical manifestations. Gastrointestinal involvement is frequent, affecting up to 20% of patients and significantly contributing to morbidity and ...
Györgyi Műzes, Ferenc Sipos
wiley +1 more source
Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment
Scientific ReportsLack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal transcriptomes and protein expression represents a major gap in the management of these patients.
Vishwesh Bharadiya +7 more
doaj +1 more source
Tissue engineering laboratory models of the small intestine. [PDF]
, 2018 In recent years, three-dimensional (3D) cell culture models of the small intestine have gained much attention. These models support cell proliferation, migration, and differentiation, and encourage tissue organization which is not possible in two ...
Dosh, Rasha +3 more
core +1 more source
Sixth European seminar in virology on virus\u2013host interaction at single cell and organism level [PDF]
, 2018 The 6th European Seminar in Virology (EuSeV) was held in Bertinoro, Italy, 22\u201324 June 2018, and brought together international scientists and young researchers working in the field of Virology.
Pal\uf9, Giorgio +4 more
core +1 more source