Results 91 to 100 of about 34,062 (265)

Modulation of Endoplasmic Reticulum Stress by Selected Polyphenols from Sambucus ebulus L. Fruit

Plants
When misfolded or unfolded proteins accumulate in the endoplasmic reticulum (ER), ER stress occurs, which contributes to the pathogenesis of various diseases. A previous study from our research group showed that aqueous extract from the Sambucus ebulus L.
Stoyan Stoyanov, Momchil Barbolov, Galina Yaneva, Oskan Tasinov   +3 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

(-)-Epicatechin does not sensitize normal cells to radiation.

, 2014
(A) 20 µM (-)-Epicatechin does not sensitize HNF cells to radiation (REF = 0.9). (B) (-)-Epicatechin alone does not inhibit colony formation in HNF (p>0.05).
Maik Hüttemann (479906), Hosam A. Elbaz (582932), Jenney Liu (582934), Steven P. Zielske (582935), Icksoo Lee (479905), Deborah A. Antwih (582933)   +5 more
core   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Effect of (−)-Epicatechin on Mitochondrial Homeostasis in Skeletal Muscle of Female Obese Rats

Molecules
Background: Main risk factors associated with the development of sarcopenia (coexistence of muscle mass loss and dysfunction) are a sedentary lifestyle coupled with obesity.
Elena de la C. Herrera-Cogco, Socorro Herrera-Meza, Yuridia Martínez-Meza, Javier Pérez-Durán, Guillermo Ceballos, Enrique Méndez-Bolaina, Nayelli Nájera   +6 more
doaj   +1 more source

Epicatechin Provides Antioxidant Protection to Bovine Spermatozoa Subjected to Induced Oxidative Stress

Molecules, 2019
Epicatechin (EPI) is a natural flavonoid with antibacterial, anti-inflammatory and anti-cancer properties. Furthermore, the molecule exhibits powerful reactive oxygen species (ROS) scavenging and metal-chelating properties. In this study, we assessed the
Eva Tvrda, Peter Straka, Drahomir Galbavy, Peter Ivanic   +3 more
doaj   +1 more source

Effect of (–)-epicatechin-3-gallate and (–)-epigallocatechin-3-gallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking

, 2018
Green tea has attracted great interest as a cancer prevention agent. Interactions of tea polyphenols with serum albumin may influence the efficacy of drugs.
Jun Han (231645), Liying Liu (132271), Lixia Yuan (1747378), Min Liu (45756), Yabo Shi (5957945), Hui Yan (117134)   +5 more
core   +1 more source

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka   +5 more
wiley   +1 more source

Protective Effects Induced by a Novel Food Supplement Based on Epilobium angustifolium, Ptychopetalum olacoides, Ginkgo biloba, and Equisetum arvense Extracts and Citrulline in the Lower Urinary Tract: Preclinical and Clinical Evidence

Phytotherapy Research, EarlyView.
ABSTRACT Oxyfil is a dietary supplement including plant extracts from Epilobium angustifolium, Ptychopetalum olacoides (Muira puama), Ginkgo biloba, and Equisetum arvense and citrulline. The aim of the study was to investigate the protective effects on prostatic muscles of the Oxyfil formulation in an in vitro experimental model consisting of isolated ...
Annalisa Chiavaroli, Alessandra Acquaviva, Simonetta Cristina Di Simone, Stefano Salvatore, Silvia Messina, Carolina Morgante, Chiara Lupi, Silvia Villa, Gokhan Zengin, Giustino Orlando, Luigi Menghini, Claudio Ferrante, Luigi Schips, Luca Cindolo, Michele Marchioni   +14 more
wiley   +1 more source