Results 1 to 10 of about 6,130 (95)

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates? [PDF]

Frontiers in Genetics
Certain aspects of animal ageing can be quantified using molecular clocks or machine learning algorithms that are trained on specific omics data, with epigenetic clocks based on DNA methylation (DNAm) garnering the most attention.
Ryszard Maleszka
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What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations [PDF]

Clinical Epigenetics
DNA methylation (DNAm) has been touted as a potential unified marker of the contributions of both inherited and environmental factors on an individual’s health.
Samuel F. P. Gibbs, Anna P. Pilbrow, Katrina K. Poppe, Nikki J. Earle, Gregory T. Jones, Allamanda F. Faatoese   +5 more
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An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes [PDF]

Nature Communications
Epigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes – typically using small datasets and a limited number of clocks. Here, we present a large-scale (n = 
Christos Mavrommatis, Daniel W. Belsky, Kejun Ying, Mahdi Moqri, Archie Campbell, Anne Richmond, Vadim N. Gladyshev, Tamir Chandra, Daniel L. McCartney, Riccardo E. Marioni   +9 more
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Assessing the utility of epigenetic clocks for health prediction in South Korean [PDF]

Frontiers in Aging
Epigenetic clocks have been developed to track both chronological age and biological age, which is defined by physiological biomarkers and the risk of adverse health outcomes.
Dong Jun Kim, Joon Ho Kang, Ji-Woong Kim, Sun bin Kim, Young Kee Lee, Myeong Jae Cheon, Byung-Chul Lee   +6 more
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Epigenetic clocks in the pediatric population: when and why they tick?

Chinese Medical Journal, 2021
. Recent research efforts have provided compelling evidence of genome-wide DNA methylation alterations in pediatrics. It is currently well established that epigenetic clocks, composed of DNA methylation sites, can estimate the gestational and ...
Jing Wang, Wen-Hao Zhou, Jing Ni
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Characteristics of Epigenetic Clocks Across Blood and Brain Tissue in Older Women and Men

Frontiers in Neuroscience, 2021
Epigenetic clocks are among the most promising biomarkers of aging. It is particularly important to establish biomarkers of brain aging to better understand neurodegenerative diseases.
Francine Grodstein, Francine Grodstein, Bernardo Lemos, Lei Yu, Lei Yu, Artemis Iatrou, Philip L. De Jager, David A. Bennett, David A. Bennett   +8 more
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Assessing the Causal Association between Biological Aging Biomarkers and the Development of Cerebral Small Vessel Disease: A Mendelian Randomization Study

Biology, 2023
Biological aging biomarkers, such as leukocyte telomere length (LTL) and epigenetic clocks, have been associated with the risk of cerebral small vessel disease (CSVD) in several observational studies.
Biying Lin, Yuzhu Mu, Zhongxiang Ding
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Age estimation in fishes using epigenetic clocks: Applications to fisheries management and conservation biology

Frontiers in Marine Science, 2023
The distribution of age classes is a key demographic parameter of populations and thus proper age estimation is crucial for fisheries management and for conservation biology.
Francesc Piferrer, Dafni Anastasiadi
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Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression

Genome Biology, 2022
Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG dinucleotides to accurately predict individual chronological age.
Thomas H. Jonkman, Koen F. Dekkers, Roderick C. Slieker, Crystal D. Grant, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Lude Franke, Jan H. Veldink, Dorret I. Boomsma, P. Eline Slagboom, B. I. O. S. Consortium, Bastiaan T. Heijmans   +11 more
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Evaluation of pediatric epigenetic clocks across multiple tissues

Clinical Epigenetics, 2023
Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden, Leonardo Trasande, Julie B. Herbstman, Carlos A. Camargo, Nicole R. Bush, Anne L. Dunlop, Dana M. Dabelea, Margaret R. Karagas, Carrie V. Breton, Carole Ober, Todd M. Everson, Grier P. Page, Christine Ladd-Acosta, on behalf of program collaborators for Environmental influences on Child Health Outcomes   +28 more
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