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Designing Epigenetic Clocks for Wildlife Research. [PDF]
Mol Ecol ResourABSTRACTThe applications of epigenetic clocks – statistical models that predict an individual's age based on DNA methylation patterns – are expanding in wildlife conservation and management. This growing interest highlights the need for field‐specific design best practices.
Newediuk L +5 more
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Epigenetic Clock: DNA Methylation in Aging [PDF]
Stem Cells International, 2020 Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regulators involved in this process ...
Shuang Jiang, Yuchen Guo
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Epigenetic clocks and programmatic aging. [PDF]
Ageing Res Rev, 2023 The last decade has seen remarkable progress in the characterization of methylation clocks that track biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms.
Gems D, Virk RS, de Magalhães JP.
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Circadian clocks, epigenetics, and cancer [PDF]
Current Opinion in Oncology, 2015 The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways.
Masri, Selma +2 more
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Cardiovascular health and four epigenetic clocks
Clinical Epigenetics, 2022 Abstract Background Cardiovascular health (CVH) was defined by the American Heart Association as an integrative idealness of seven clinical or lifestyle factors. Based on populations of European ancestry, recent studies have shown that ideal CVH is associated with a slower aging rate. The aging rate is measured by levels
Yun-Hsiang Lo, Wan-Yu Lin
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Novel feature selection methods for construction of accurate epigenetic clocks.
PLoS Computational Biology, 2022 Epigenetic clocks allow us to accurately predict the age and future health of individuals based on the methylation status of specific CpG sites in the genome and are a powerful tool to measure the effectiveness of longevity interventions.
Adam Li +6 more
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Epigenetics, 2022 Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells. Their success as a measure of biological ageing has prompted research on the connection between epigenetic pathways of ageing and the socioeconomic gradient in ...
Lauren L. Schmitz +11 more
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Genome Biology, 2022 Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples.
James E. Barrett +14 more
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An evolutionary epigenetic clock in plants
Science, 2023 Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (~10 5 to 10 8 years). However, classical DNA-based clocks tick too slowly to inform us about the recent past.
Yao, N. +12 more
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Circadian clock: linking epigenetics to aging [PDF]
Current Opinion in Genetics & Development, 2014 Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features.
Orozco-Solis, Ricardo +1 more
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