Results 21 to 30 of about 6,200 (160)

Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity

GeroScience, 2023
Abstract Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than ...
Dec, Eric, Clement, James, Cheng, Kaiyang, Church, George M., Fossel, Michael B., Rehkopf, David H., Rosero-Bixby, Luis, Kobor, Michael S., Lin, David TS., Lu, Ake T., Fei, Zhe, Guo, Wei, Chew, Yap Ching, Yang, Xiaojing, Putra, Sulistyo E. Dwi, Reiner, Alex P., Correa, Adolfo, Vilalta, Adrian, Pirazzini, Chiara, Passarino, Giuseppe, Monti, Daniela, Arosio, Beatrice, Garagnani, Paolo, Franceschi, Claudio, Horvath, Steve   +24 more
openaire   +6 more sources

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons

Molecular Brain, 2021
Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system.
Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak P. Srivastava, Nicholas J. Bray, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Ehsan Pishva, Emma L. Dempster, Katie Lunnon, Jonathan Mill, Eilis Hannon   +24 more
doaj   +1 more source

Epigenetic clock and methylation studies in cats [PDF]

GeroScience, 2021
Abstract Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in ...
Ken Raj, Balazs Szladovits, Amin Haghani, Joseph A. Zoller, Caesar Z. Li, Pete Black, Dewey Maddox, Todd R. Robeck, Steve Horvath   +8 more
openaire   +4 more sources

Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Clinical Epigenetics, 2023
Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui, Fathima Humaira Amanullah, Mohamad Saad, Sara Taleb, Martina Bradic, Andre Megarbane, Ali Ait Hssain, Charbel Abi Khalil, Nady El Hajj   +8 more
doaj   +1 more source

Developmental Tuning of Epigenetic Clock [PDF]

Frontiers in Genetics, 2018
Research in the field of gerontology has traditionally focused on later life stages. There is increasing evidence, however, that both the rate of age-related functional decline and the later-life health status can be programmed during early development.
openaire   +3 more sources

An epigenetic clock controls aging [PDF]

Biogerontology, 2015
We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have seen that signaling chemistry can make dramatic differences in life span, and that single molecules can significantly affect ...
openaire   +3 more sources

Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry, 2023
Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li, Xiaofen Zong, David Li, Ying He, Jinsong Tang, Maolin Hu, Xiaogang Chen   +6 more
doaj   +1 more source

DNA methylation accelerated age as captured by epigenetic clocks influences breast cancer risk

Frontiers in Oncology, 2023
IntroductionBreast cancer continues to be the leading form of cancer among women in the United States. Additionally, disparities across the breast cancer continuum continue to increase for women of historically marginalized populations.
Celina I. Valencia, Devin Saunders, Jennifer Daw, Adria Vasquez   +3 more
doaj   +1 more source

What makes biological age epigenetic clocks tick. [PDF]

Nat Aging
Moqri M, Poganik JR, Horvath S, Gladyshev VN.   +3 more
europepmc   +3 more sources

An epigenetic clock for human skeletal muscle [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2019
AbstractBackgroundAgeing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the original pan-tissue epigenetic clock did not include skeletal muscle samples, and hence exhibited a strong deviation between ...
Voisin, S, Harvey, NR, Haupt, LM, Griffiths, LR, Ashton, KJ, Coffey, VG, Doering, TM, Thompson, JM, Benedict, C, Cedernaes, J, Lindholm, ME, Craig, JM, Rowlands, DS, Sharples, AP, Horvath, S, Eynon, N   +15 more
openaire   +7 more sources