Results 41 to 50 of about 6,200 (160)
Neurobiology of Disease, 2021 Epigenetic clocks are calculated by combining DNA methylation states across select CpG sites to estimate biologic age, and have been noted as the most successful markers of biologic aging to date.
Francine Grodstein +10 more
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Epigenetic/circadian clocks and PCOS
Human ReproductionAbstract Polycystic ovary syndrome (PCOS) affects 6–20% of reproductive-aged women. It is associated with increased risks of metabolic syndrome, Type 2 diabetes, cardiovascular diseases, mood disorders, endometrial cancer and non-alcoholic fatty liver disease.
Camille Vatier, Sophie Christin-Maitre
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Identifying epigenetic aging moderators using the epigenetic pacemaker
Frontiers in BioinformaticsEpigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age acceleration ...
Colin Farrell +5 more
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Epigenetic clock as a correlate of anxiety
NeuroImage: Clinical, 2020 DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one's epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder, as compared with controls. Since MDD is highly correlated with anxiety, we hypothesized that symptoms
Marečková, Klára +8 more
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Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder
Frontiers in GeneticsMathematical algorithms known as “epigenetic clocks” use methylation values at a set of CpG sites to estimate the biological age of an individual in a tissue-specific manner. These clocks have demonstrated both acceleration and delays in epigenetic aging
Gauri G. Shastri +9 more
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Epigenetic clock and methylation studies in elephants
Aging Cell, 2020 ABSTRACTAge-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age (“epigenetic clocks”) in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants.
Natalia A. Prado +11 more
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Perfect timing: Epigenetic regulation of the circadian clock [PDF]
FEBS Letters, 2011 In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post‐genetic molecular mechanism is one of the routes by which phenotype is shaped.
Ripperger Jürgen A, Merrow Martha
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Applicability of epigenetic age models to next-generation methylation arrays
Genome MedicineBackground Epigenetic clocks are mathematical models used to estimate epigenetic age based on DNA methylation at specific CpG sites. As new methylation microarrays are developed and older models discontinued, existing epigenetic clocks might become ...
Leonardo D. Garma +1 more
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BMC Genomics, 2020 Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina HumanMethylation450 BeadChip (450 K) which ...
Yunsung Lee +18 more
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Time's up: Epigenetic clocks in plants
Current Opinion in Plant BiologyFor over a decade, the animal field has led the way in using DNA methylation measurements to construct epigenetic clocks of aging. These clocks can predict organismal age with a level of accuracy that surpasses any other molecular proxy known to date. Evidence is finally emerging that epigenetic clocks also exist in plants. However, these clocks appear
Vo, Binh Thanh +2 more
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