Results 111 to 120 of about 1,435 (170)

REDIportal: toward an integrated view of the A-to-I editing [PDF]

A-to-I RNA editing is the most common non-transient epitranscriptome modification. It plays several roles in human physiology and has been linked to several disorders.
Cohen-Fultheim, Roni, D'Addabbo, Pietro, Eisenberg, Eli, Fonzino, Adriano, Green, Andrew, Levanon, Erez Y, Luo, Jie, Lussi, Yvonne, Martin, Maria-Jesus, Mazzacuva, Pietro Luca, Pesole, Graziano, Picardi, Ernesto, Prakash, Ananth, Silvestris, Domenico Alessandro, Sweeney, Blake, Twersky, Itamar, Vizcaino, Juan Antonio, Yates, Andy   +17 more
core   +1 more source

Cell‐Type‐Specific WTAP and ALKBH5‐Mediated m6A Methylation Orchestrates Mental Disorders via Gut‐Brain Axis Metabolite Signaling: Multi‐Omics Evidence and Pyroptosis‐Associated Loop Mechanism

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
MR analysis revealed distinct causal associations of m6A modifiers (WTAP/ALKBH5) with mental disorders. Gut microbiota (GCA‐900066755, Bacillus) and CSF metabolites (theophylline, isoleucine) mediated 5.06%–45.28% of effects via pathways such as WTAP → GCA‐900066755 → theophylline → ADHD. Single‐cell eQTL linked WTAP‐mediated ADHD risk to XCL1‐NK cells,
Jingjing Zhang, Xue Liu, Xiaoming Liu, Liqun Zhao, Junjie Bi   +4 more
wiley   +1 more source

Unraveling the dual role of METTL3-mediated m6A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications

Cancer Biology & Therapy
Bladder cancer (BC) remains challenging due to its recurrence and metastasis, with METTL3-mediated m6 A RNA modification emerging as a key oncogenic driver. This review synthesizes METTL3’s roles in BC progression, including tumor initiation, metastasis,
Hua Chun, Kangzhuo Baima
doaj   +1 more source

From RNA and its NAD-cap: Exploring T4 phage infection from an epitranscriptomic perspective [PDF]

Bacteriophages are viruses with the ability to specifically infect and kill bacteria. Bacteriophage research has shaped our understanding of fundamental biological principles and provided tools for molecular biology, but it has long been forgotten. Thus,
Wolfram-Schauerte, Maik
core   +1 more source

N6-methyladenosine RNA modifications in myogenesis / narrative competence and cognitive mapping as a culturally sustaining pedagogy in the education of emergent bilinguals [PDF]

, 2022
Myogenesis involves skeletal muscle stem cells (MuSCs) that produce and regenerate skeletal muscle during regular growth and repair. However, when this system fails to function normally, it can lead to musculoskeletal diseases like Duchenne Muscular ...
Infantado, Marina Danielle
core   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
wiley   +1 more source

Introduction to ‘The Epitranscriptome’

RSC Chemical Biology
Ralph Kleiner (Princeton University, USA), Claudia Höbartner (University of Würzburg, Germany) and Guifang Jia (Peking University, China) introduce the themed collection on ‘The Epitranscriptome’.
Kleiner, Ralph E., Höbartner, Claudia, Jia, Guifang   +2 more
openaire   +2 more sources

Identification and characterization of novel methyltransferases [PDF]

, 2020
So far 172 different types of nucleic acid modifications had been identified. However, for many RNA and DNA modifications the function(s) and the modifying enzymes (”writers”) are still not known. In my Ph.D.
Ignatova, Valentina
core  

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Science of omics: a molecular space odyssey

Experimental Physiology, EarlyView.
Salomé Coppens, Christophe Hirtz, Margaux Vignon, Damian M. Bailey   +3 more
wiley   +1 more source