Results 121 to 130 of about 1,435 (170)

ALKBH5‐Driven m6A Demethylation Boosts Inflammation and Autophagy in LPS‐Stimulated Macrophages

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Purpose Acute Respiratory Distress Syndrome (ARDS) remains a critical health threat with limited pharmacological treatments. This study investigates the role of the N6‐methyladenosine (m6A) demethylase AlkB homolog 5 (ALKBH5) in alveolar macrophages and its subsequent impact on inflammation and autophagy during ARDS pathogenesis.
Gui Wang, Ting Zhou, Shujun Zhou
wiley   +1 more source

The epitranscriptome and synaptic plasticity

Current Opinion in Neurobiology, 2019
RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years, technological advances improving our ability to identify mRNA modifications, coupled with the discovery of proteins that add and remove these ...
Mathieu N Flamand, Kate D Meyer
openaire   +3 more sources

Epitranscriptomic regulations in the heart

Physiological Research
RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6 ...
Benák, D. (Daniel), Kolář, F. (František), Hlaváčková, M. (Markéta)   +2 more
openaire   +3 more sources

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Emerging role of m6A modification in ovarian cancer: progression, drug resistance, and therapeutic prospects

Frontiers in Oncology
Ovarian Cancer (OC) ranks as a prominent contributor to mortality among female reproductive system associated cancers, particularly the prevalent subtype epithelial Ovarian Cancer (EOC).
Shahil Alam, Pankaj Kumar Giri
doaj   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley   +1 more source

Epitranscriptomic RNA m6A Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities

Advanced Science
Significant advances in the development of new cancer therapies have given rise to multiple novel therapeutic options in chemotherapy, radiotherapy, immunotherapy, and targeted therapies.
Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang   +2 more
doaj   +1 more source

Unveil Intrahepatic Cholangiocarcinoma Heterogeneity through the Lens of Omics and Multi-Omics Approaches [PDF]

Simple Summary Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver cancer leading to death in 10-15% of cases. In recent years, the iCCA worldwide incidence has been increasing, and research is currently focused on identifying ...
Barbagallo, Cristina, Corbella, Eleonora, Mancone, Carmine, Maras, Bruno, Mignogna, Giuseppina, Peres, Marco, Porreca, Veronica, Ragusa, Marco, Stella, Michele   +8 more
core   +1 more source

CHEMICAL SYNTHESIS AND BIOLOGICAL APPLICATION OF SENSITIVE RNA [PDF]

In the field of epigenetics - the dynamic collection of chemical modifications that overlay DNA/RNA - there is increasing interest in the potential for therapeutic and research-based utilization of the epitranscriptomics: those epigenetic modifications ...
Apostle, Alexander T.
core   +2 more sources