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$3 million grant will fund search for biological basis of major depressive disorder [PDF]
, 2019 Hansen, Jeff
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The epitranscriptome in gastric cancer: the role of m6A mRNA modifications [PDF]
, 2020 Luís Filipe Costa Póvoas
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AUTOPHAGY AND APOPTOSIS MODULATION BY AQUEOUS EXTRACTS FROM LEAVES AND RHIZOMES OF Posidonia oceanica ON HEPG2 HEPATOCARCINOMA CELLS [PDF]
, 2023 Aiti VIZZINI +9 more
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Epitranscriptomic analyses of the dihydrouridine RNA modification in Bacteria and Eukarya [PDF]
, 2018 Finet, Olivier
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Detecting the epitranscriptome
WIREs RNA, 2021AbstractRNA modifications and their corresponding epitranscriptomic writer and eraser enzymes regulate gene expression. Altered RNA modification levels, dysregulated writers, and sequence changes that disrupt epitranscriptomic marks have been linked to mitochondrial and neurological diseases, cancer, and multifactorial disorders.
Anwesha Sarkar +6 more
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Epitranscriptomics in metabolic disease
Nature Metabolism, 2023While epigenetic modifications of DNA and histones play main roles in gene transcription regulation, recently discovered post-transcriptional RNA modifications, known as epitranscriptomic modifications, have been found to have a profound impact on gene expression by regulating RNA stability, localization and decoding efficiency.
Yoshihiro Matsumura +2 more
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The epitranscriptome beyond m6A
Nature Reviews Genetics, 2020Following its transcription, RNA can be modified by >170 chemically distinct types of modifications - the epitranscriptome. In recent years, there have been substantial efforts to uncover and characterize the modifications present on mRNA, motivated by the potential of such modifications to regulate mRNA fate and by discoveries and advances in our ...
David Wiener, Schraga Schwartz
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Epitranscriptomic technologies and analyses
Science China Life Sciences, 2020RNA can interact with RNA-binding proteins (RBPs), mRNA, or other non-coding RNAs (ncRNAs) to form complex regulatory networks. High-throughput CLIP-seq, degradome-seq, and RNA-RNA interactome sequencing methods represent powerful approaches to identify biologically relevant ncRNA-target and protein-ncRNA interactions.
Xiaoyu, Li +8 more
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Epitranscriptomics in fibroblasts and fibrosis
American Journal of Physiology-Cell Physiology, 2022Fibroblasts play an important role in the pathogenic mechanisms of several socially significant diseases, including pulmonary and cardiovascular fibrosis, liver cirrhosis, systemic sclerosis, progressive kidney disease. The alterations of the epitranscriptome, including more than 170 distinct posttranscriptional RNA modifications or editing events ...
Mirolyuba Ilieva, Shizuka Uchida
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