Results 41 to 50 of about 1,435 (170)
Deciphering the epitranscriptome: a green perspective [PDF]
, 2016 The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core +1 more source
Metabolic-associated fatty liver disease: from simple steatosis towards liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, endorsed by the Spanish Association for the Study of the Liver (AEEH) [PDF]
, 2022 This is a meeting report of the 3rd Translational Hepatology Meeting held in Alicante, Spain, in October 2021. The meeting, which was organized by the Spanish Association for the Study of the Liver (AEEH), provided an update on the recent advances in the
Albillos, Agustín +23 more
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Epitranscriptomic regulation of insecticide resistance [PDF]
Science Advances, 2021 A cytochrome P450 that confers insecticide resistance in whitefly is regulated by an epitranscriptomic mechanism.
Xin Yang +17 more
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More than a duologue: In-depth insights into epitranscriptomics and ferroptosis
Frontiers in Cell and Developmental Biology, 2022 Beyond transcription, RNA molecules are enzymatically modified to influence the biological functions of living organisms. The term “epitranscriptomics” describes the changes in RNA strands aside from altering the innate sequences.
Justin Chak Ting Cheung +5 more
doaj +1 more source
Dawn of Epitranscriptomic Medicine [PDF]
Circulation: Genomic and Precision Medicine, 2018 Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
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Epitranscriptomics for Biomedical Discovery [PDF]
, 2017 Epitranscriptomics is a newly burgeoning field pertaining to the complete delineation and elucidation of chemical modifications of nucleotides found within all classes of RNA that do not involve a change in the ribonucleotide sequence.
Heruth, Daniel P. +6 more
core +1 more source
Cracking the epitranscriptome [PDF]
RNA, 2016 Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made ...
openaire +2 more sources
Emerging Roles of Long Noncoding RNAs in Breast Cancer Epigenetics and Epitranscriptomics
Frontiers in Cell and Developmental Biology, 2022 Breast carcinogenesis is a multistep process that involves both genetic and epigenetic changes. Epigenetics refers to reversible changes in gene expression that are not accompanied by changes in gene sequence.
Elżbieta Wanowska +3 more
doaj +1 more source
The mammalian mitochondrial epitranscriptome
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression.
Rebelo-Guiomar, Pedro +3 more
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The Epitranscriptome and Innate Immunity [PDF]
PLOS Genetics, 2015 Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts.
O'Connell, Mary +2 more
openaire +4 more sources