Results 51 to 60 of about 1,435 (170)

Epitranscriptomic modifications for enhancing abiotic stress resistance in plants

Frontiers in Plant Science
Climate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at the post-/transcriptional level. Gene regulation in plants is
Yunmin Zeng, Yunmin Zeng, Abid Muhammad, Lingyun Wan, Chenlu Gao, Pinyao Zhao, Ahmed H. El-Sappah, Ahmed H. El-Sappah   +7 more
doaj   +1 more source

Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression

Frontiers in Cell and Developmental Biology, 2021
Gene regulation depends on dynamic and reversibly modifiable biological and chemical information in the epigenome/epitranscriptome. Accumulating evidence suggests that messenger RNAs (mRNAs) are generated in flashing bursts in the cells in a precisely ...
Suresh Kumar, Trilochan Mohapatra
doaj   +1 more source

mRNA epitranscriptomics

RNA
Epitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer, Kate D., Pan, Tao
openaire   +2 more sources

Significant epitranscriptomes in heterogeneous cancer [PDF]

Cancer Science, 2019
AbstractPrecision medicine places significant emphasis on techniques for the identification of DNA mutations and gene expression by deep sequencing of gene panels to obtain medical data. However, other diverse information that is not easily readable using bioinformatics, including RNA modifications, has emerged as a novel diagnostic and innovative ...
Masamitsu Konno, Masateru Taniguchi, Hideshi Ishii   +2 more
openaire   +2 more sources

Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined.
Beijian Zhang, Beijian Zhang, Beijian Zhang, Yamei Xu, Xiaotong Cui, Hao Jiang, Hao Jiang, Hao Jiang, Wei Luo, Wei Luo, Wei Luo, Xinyu Weng, Xinyu Weng, Xinyu Weng, Yun Wang, Yun Wang, Yun Wang, Yun Wang, Yuhong Zhao, Aijun Sun, Aijun Sun, Aijun Sun, Aijun Sun, Junbo Ge, Junbo Ge, Junbo Ge, Junbo Ge   +26 more
doaj   +1 more source

Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer

Frontiers in Cell and Developmental Biology, 2019
RNA chemical modifications in coding and non-coding RNAs have been known for decades. They are generally installed by specific enzymes and, in some cases, can be read and erased by other specific proteins. The impact of RNA chemical modifications on gene
Francesco Fazi, Alessandro Fatica
doaj   +1 more source

Charting the unknown epitranscriptome

Nature Reviews Molecular Cell Biology, 2017
RNA modifications can alter RNA structure-function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the ...
Novoa Pardo, EM, Mason, CE, Mattick, JS
openaire   +3 more sources

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

How Do You Identify m6 A Methylation in Transcriptomes at High Resolution? A Comparison of Recent Datasets

Frontiers in Genetics, 2020
A flurry of methods has been developed in recent years to identify N6-methyladenosine (m6A) sites across transcriptomes at high resolution. This raises the need to understand both the common features and those that are unique to each method.
Charlotte Capitanchik, Patrick Toolan-Kerr, Patrick Toolan-Kerr, Nicholas M. Luscombe, Nicholas M. Luscombe, Nicholas M. Luscombe, Jernej Ule, Jernej Ule   +7 more
doaj   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source