Results 51 to 60 of about 25,445 (232)

Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus [PDF]

, 2017
Background: A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a six month upsurge in invasive GAS disease in the UK.
Afshar, B, Al-Shahib, A, Efstratiou, A, Holden, M T G, Lamagni, T L, Smith, K C, Sriskandan, S, Turner, C E, Underwood, A   +8 more
core   +3 more sources

Mouse liver contains a Pseudomonas aeruginosa exotoxin A-binding protein [PDF]

Infection and Immunity, 1991
The opportunistic pathogen Pseudomonas aeruginosa produces several potential virulence factors, including the ADP-ribosylating toxin, exotoxin A (PE). Studies using a burned mouse model have shown that PE consistently inhibits protein synthesis and depletes elongation factor 2 in mouse liver and variably in other organs.
J J, Forristal, M R, Thompson, R E, Morris, C B, Saelinger   +3 more
openaire   +2 more sources

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A

Toxins, 2016
Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins that have been evaluated in clinical trials.
Gilad Kaplan, Fred Lee, Masanori Onda, Emily Kolyvas, Gaurav Bhardwaj, David Baker, Ira Pastan   +6 more
doaj   +1 more source

LINK BETWEEN SOME VIRULNCE FACTORS GENES AND ANTIBACTERIAL RESISTANCE OF PSEUDOMONAS AERUGINOSA

The Iraqi Journal of Agricultural science, 2022
The research was aimed to demonstrate the frequency of virulence factors genes (exoenzyme S and exotoxin A) and to express their relationship to antibacterial resistance among Pseudomonas aeruginosa isolated from patients suffering from otitis externa ...
Aida H. Ibrahim
doaj   +1 more source

Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]

, 2013
Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Gruber, C.J., Ilangovan, Aravindan, Lang, S., Redzej, Adam, Topf, Maya, Waksman, Gabriel, Zangger, K., Zechner, E.L.   +7 more
core   +1 more source

Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real‐Time PCR Assay

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Gut microbiota plays a key role in triggering various diseases. However, translocation studies focus on bacteria, neglecting fungal elements, while fungi seem also involved in triggering various diseases. Aim of this study was to assess whether fungal elements were able to translocate in patients with AUD (alcohol use disorder) and to verify ...
Nathalie Pansu, Pascal Drakulovski, Donika Krasteva, Virginie Bellet, Jean‐Philippe Lavigne, Catherine Dunyach‐Remy, Florian Salipante, Alex Yahiaoui‐Martinez, Hélène Donnadieu‐Rigole, Sébastien Bertout   +9 more
wiley   +1 more source

Spontaneous Clearance of a Secondary Buruli Ulcer Lesion Emerging Ten Months after Completion of Chemotherapy-A Case Report from Togo [PDF]

, 2012
Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production of antibodies that could neutralize the cytotoxic activities of ...
Abiba Banla Kere, Adolf Diefenhardt, Basil Kobara, Dominik Symank, Ebekalisai Piten, Franz Wiedemann, Gisela Bretzel, Harald Hoffmann, Issaka Maman, Jörg Nitschke, Komi Amekuse, Kossi Badziklou, Marcus Beissner, Moritz Jansson, Richard O. Phillips, Thomas Löscher   +15 more
core   +5 more sources

LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin

Communications Biology, 2022
Clostridium novyi alpha-toxin (Tcnα) also uses LRP1 and Megalin as cellular entry receptors besides LDLR, and this might be a response to cell-type dependent receptor availability for the exotoxin.
Yao Zhou, Danyang Li, Diyin Li, Aizhong Chen, Liuqing He, Jianhua Luo, Liang Tao   +6 more
doaj   +1 more source

Equine botulism

Equine Veterinary Journal, Volume 58, Issue 2, Page 333-347, March 2026.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik, Robert Whitlock, Amy Johnson   +2 more
wiley   +1 more source