Galantamine-loaded PLGA nanoparticles reduce oxidative stress and inflammation in a rat model of spinal cord injury [PDF]
Scientific ReportsSpinal cord injury (SCI) represents a debilitating condition with no effective treatments currently available. Previous research demonstrated that galantamine improves functional outcomes in SCI models. However, systemic administration results in limited
Fernanda Stapenhorst Franca +7 more
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The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice [PDF]
Scientific ReportsAcute respiratory distress syndrome (ARDS) is a life-threatening form of acute lung injury (ALI), which is a common cause of respiratory failure and high mortality in critically ill patients.
Aidan Falvey +10 more
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Galantamine ameliorates experimental pancreatitis
Molecular Medicine, 2023 Background Acute pancreatitis is a common and serious inflammatory condition currently lacking disease modifying therapy. The cholinergic anti-inflammatory pathway (CAP) is a potent protective anti-inflammatory response activated by vagus nerve-dependent
Dane A. Thompson +9 more
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Reactions Weekly, 2017 In 1906, Alois Alzheimer, a psychiatrist from Munich, Germany, described a new mental illness, which is a progressively damaging brain disorder, leading to neurodegeneration, erosion of basic intellectual functions along with histological changes, and ultimately the patient’s death.
John C. Courtney +1 more
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Galantamine plasma concentration and cognitive response in Alzheimer’s disease [PDF]
PeerJ, 2019 Background Galantamine has been approved for the treatment of Alzheimer’s disease (AD). However, there are few studies which have reported the association between cognitive responses and galantamine plasma concentration.
Yi-Ting Lin +3 more
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Galantamine attenuates autoinflammation in a mouse model of familial mediterranean fever
Molecular Medicine, 2022 Background Autoinflammatory diseases, a diverse group of inherited conditions characterized by excessive innate immune activation, have limited therapeutic options.
Ibrahim T. Mughrabi +10 more
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Galantamine improves glycemic control and diabetic nephropathy in Leprdb/db mice
Scientific Reports, 2023 Galantamine, a centrally acting acetylcholinesterase inhibitor, has been shown to attenuate inflammation and insulin resistance in patients with metabolic syndrome.
Qinghe Meng +5 more
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Pharmaceuticals, 2021 Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoea (5–
Jan Bures +8 more
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The Effect of Galantamine on Liver Function in Hepatic Ischemia/Reperfusion Injury in Rats [PDF]
Disease and Diagnosis, 2019 Background: Hepatic ischemia-reperfusion (IR) injury may affect different biological and functional roles of the liver. The present study aims to evaluate the effects of galantamine as a cholinergic agent on the acute and late phases of IR. Materials and
Majid Askaripour +2 more
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Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To evaluate the effects of PHA-543613 (α7-nAChR agonist) and galantamine (acetylcholinesterase inhibitor (AChEI)) on recognition memory and neurovascular coupling (NVC) response in beta-amyloid (Aβ) 25-35-treated mice.
Saeed Sadigh-Eteghad +3 more
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