Results 11 to 20 of about 23,209 (275)

Galantamine improves glycemic control and diabetic nephropathy in Leprdb/db mice

Scientific Reports, 2023
Galantamine, a centrally acting acetylcholinesterase inhibitor, has been shown to attenuate inflammation and insulin resistance in patients with metabolic syndrome.
Qinghe Meng, Julia Ma, Liye Suo, Napat Pruekprasert, Prithi Chakrapani, Robert N. Cooney   +5 more
doaj   +2 more sources

Galantamine ameliorates hyperoxia-induced brain injury in neonatal mice

Frontiers in Neuroscience, 2023
Introduction:Prolonged oxygen therapy in preterm infants often leads to cognitive impairment. Hyperoxia leads to excess free radical production with subsequent neuroinflammation, astrogliosis, microgliosis and apoptosis. We hypothesized that Galantamine,
Nahla Zaghloul, Naomi S. Cohen, Kamesh R. Ayasolla, Hsiu-Ling Li, Dalibor Kurepa, Mohamed N. Ahmed   +5 more
doaj   +2 more sources

Galantamine prevents and reverses neuroimmune induction and loss of adult hippocampal neurogenesis following adolescent alcohol exposure

Journal of Neuroinflammation, 2021
Background Binge ethanol exposure during adolescence reduces hippocampal neurogenesis, a reduction which persists throughout adulthood despite abstinence.
Victoria Macht, Ryan Vetreno, Natalie Elchert, Fulton Crews   +3 more
doaj   +2 more sources

Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice

Journal of Neuroinflammation, 2018
Background Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases such as Alzheimer’s disease. Lipopolysaccharide (LPS, endotoxin) levels are higher in the brains of Alzheimer’s disease patients and are ...
Yi Liu, Yuyun Zhang, Xian Zheng, Tongyong Fang, Xia Yang, Xuan Luo, Anlei Guo, Kelly A. Newell, Xu-Feng Huang, Yinghua Yu   +9 more
doaj   +2 more sources

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy

Pharmaceutics, 2020
In the present study, poly(l-lactic acid) (PLLA) and poly(lactide-co-glycolide) (PLGA) hybrid nanoparticles were developed for intranasal delivery of galantamine, a drug used in severe to moderate cases of Alzheimer’s disease. Galantamine (GAL) was
Stavroula G. Nanaki, Konstantinos Spyrou, Chryssa Bekiari, Pelagia Veneti, Turki N. Baroud, Niki Karouta, Ioannis Grivas, Georgios C. Papadopoulos, Dimitrios Gournis, Dimitrios N. Bikiaris   +9 more
doaj   +2 more sources

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Gln‐1062 (MEMOGAIN) is an intranasally administered lipophilic prodrug of galantamine. Based on high brain‐to‐blood concentrations observed in pre‐clinical studies, Gln‐1062 is expected to have superior cognitive efficacy compared to oral ...
Charlotte Bakker, Jasper van derAart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. vanEsdonk, Denis G. Kay, Geert Jan Groeneveld   +7 more
doaj   +2 more sources

Hydroxypropyl Methylcellulose-Based Hydrogel Copolymeric for Controlled Delivery of Galantamine Hydrobromide in Dementia [PDF]

Processes, 2020
The study aims to prepare a smart copolymeric for controlled delivery of Galantamine hydrobromide. The synthesis of the hydrogel was executed through free radical polymerization using HPMC (Hydroxypropyl methylcellulose) and pectin as polymers and ...
Sidra Bashir, Nadiah Zafar, Noureddine Lebaz, Asif Mahmood, Abdelhamid Elaı̈ssari   +4 more
openalex   +2 more sources

Effect of high-frequency (5Hz) rTMS stimulating left DLPFC combined with galantamine on cognitive impairment after ischemic stroke and serum homocysteine and neuron-specific enolase

Frontiers in Neurology
ObjectiveTo investigate the efficacy of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) combined with galantamine in patients with cognitive impairment after stroke and its effect on serum homocysteine (Hcy) and neuron-specific ...
Guojin Hu, Li Zhang, Xiuli Sun, Lin Wang, Qian Xu, Qin Li, Wei Huang, Yao Xiao   +7 more
doaj   +2 more sources

Chitosan-Based Nanoparticles for Targeted Nasal Galantamine Delivery as a Promising Tool in Alzheimer’s Disease Therapy [PDF]

Pharmaceutics, 2023
Natural alkaloid galantamine is widely used for the treatment of mild to moderate Alzheimer’s dementia. Galantamine hydrobromide (GH) is available as fast-release tablets, extended-release capsules, and oral solutions.
Dilyana Georgieva, Denitsa Nikolova, Elena Vassileva, Bistra Kostova   +3 more
openalex   +2 more sources

Inhibition Mechanism of Fisetin on Acetylcholinesterase and its Synergistic Effect with Galantamine

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2023
Wenli shi, Wenxin Han, Yijing Liao, Jiaqi Wen, Guowen Zhang   +4 more
openalex   +2 more sources