Results 21 to 30 of about 23,209 (275)
Galantamine-Curcumin Hybrids as Dual-Site Binding Acetylcholinesterase Inhibitors [PDF]
Molecules, 2020 Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer’s disease (AD). GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE).
Georgi Stavrakov +9 more
openalex +2 more sources
Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach
Molecules, 2023 Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer’s disease (AD). Its excessive activity causes several neuronal problems, particularly psychopathies and neuronal cell death.
Luciane B. Silva +11 more
semanticscholar +1 more source
Protective Effect of Galantamine against Doxorubicin-Induced Neurotoxicity
Brain Science, 2023 Background and aims: Doxorubicin (DOX) causes cognitive impairment (chemobrain) in patients with cancer. While DOX damages the cholinergic system, few studies have focused on the protective effects of cholinergic function on chemobrain.
R. Alsikhan +3 more
semanticscholar +1 more source
Pharmaceuticals, 2021 Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoea (5–
Jan Bures +8 more
doaj +1 more source
JCI Insight, 2023 Age-associated sarcopenia, characterized by a progressive loss in muscle mass and strength, is the largest cause of frailty and disability in the elderly worldwide.
Caterina Tezze +14 more
semanticscholar +1 more source
The Effect of Galantamine on Liver Function in Hepatic Ischemia/Reperfusion Injury in Rats [PDF]
Disease and Diagnosis, 2019 Background: Hepatic ischemia-reperfusion (IR) injury may affect different biological and functional roles of the liver. The present study aims to evaluate the effects of galantamine as a cholinergic agent on the acute and late phases of IR. Materials and
Majid Askaripour +2 more
doaj +1 more source
International Journal of Molecular Sciences, 2023 Galantamine is a natural alkaloid extracted from the Amaryllidaceae plants and is used as the active ingredient of a drug approved for the treatment of the early stages of Alzheimer’s disease.
A. Kola +3 more
semanticscholar +1 more source
Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To evaluate the effects of PHA-543613 (α7-nAChR agonist) and galantamine (acetylcholinesterase inhibitor (AChEI)) on recognition memory and neurovascular coupling (NVC) response in beta-amyloid (Aβ) 25-35-treated mice.
Saeed Sadigh-Eteghad +3 more
doaj +1 more source
Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma
Neurobiology of Disease, 2020 Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to treat mild-moderate Alzheimer's ...
Sarah Naguib +4 more
doaj +1 more source
Metabolites, 2021 Alkaloids produced by the bulbs of the Amaryllidaceae are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and ...
Dana Atrahimovich +4 more
doaj +1 more source