Results 31 to 40 of about 18,363 (193)

Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats

Acta Pharmaceutica, 2023
The effects of 3R,16S-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were examined in naïve Wistar rats using standard active and passive avoidance tests.
Dimitrova Darinka, Getova Damianka, Saracheva Kremena   +2 more
doaj   +1 more source

Pharmacological Aspects of the Acetylcholinesterase Inhibitor Galantamine

Journal of Pharmacological Sciences, 2011
.: Several lines of evidence suggest that cholinergic deficits may contribute to the pathophysiology of psychiatric disorders as well as Alzheimer’s disease.
Yukio Ago, Ken Koda, Kazuhiro Takuma, Toshio Matsuda   +3 more
doaj   +1 more source

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy

Pharmaceutics, 2020
In the present study, poly(l-lactic acid) (PLLA) and poly(lactide-co-glycolide) (PLGA) hybrid nanoparticles were developed for intranasal delivery of galantamine, a drug used in severe to moderate cases of Alzheimer’s disease. Galantamine (GAL) was
Stavroula G. Nanaki, Konstantinos Spyrou, Chryssa Bekiari, Pelagia Veneti, Turki N. Baroud, Niki Karouta, Ioannis Grivas, Georgios C. Papadopoulos, Dimitrios Gournis, Dimitrios N. Bikiaris   +9 more
doaj   +1 more source

The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial

Frontiers in Immunology, 2021
Background: The metabolic syndrome (MetS) is an obesity-associated disorder of pandemic proportions and limited treatment options. Oxidative stress, low-grade inflammation and altered neural autonomic regulation, are important components and drivers of ...
Carine Teles Sangaleti, Carine Teles Sangaleti, Keyla Yukari Katayama, Kátia De Angelis, Kátia De Angelis, Tércio Lemos de Moraes, Amanda Aparecida Araújo, Heno F. Lopes, Heno F. Lopes, Cleber Camacho, Luiz Aparecido Bortolotto, Lisete Compagno Michelini, Maria Cláudia Irigoyen, Peder S. Olofsson, Peder S. Olofsson, Douglas P. Barnaby, Kevin J. Tracey, Valentin A. Pavlov, Fernanda Marciano Consolim Colombo, Fernanda Marciano Consolim Colombo   +19 more
doaj   +1 more source

The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]

, 2017
Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela, Lembo, Giuseppe, Lori, Andrea, Perrotta, Marialuisa   +3 more
core   +2 more sources

Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug.

PLoS ONE, 2015
The cholinergic anti-inflammatory pathway is one of the putative biochemical pathways that link diabetes with Alzheimer disease. Hence, we aimed to verify the potential antidiabetic effect of galantamine, unveil the possible mechanisms and evaluate its ...
Mennatallah A Ali, Hanan S El-Abhar, Maher A Kamel, Ahmed S Attia   +3 more
doaj   +1 more source

Determination of galantamine in human plasma by LC-MS/MS using carbamazepine as an internal standard: Method validation and application to a pharmacokinetic study of galantamine hydrobromide prolonged-release capsules in healthy Thai volunteers

Cogent Medicine, 2020
A rapid, sensitive and reliable LC-MS/MS method for the determination of galantamine in plasma was developed and validated for the pharmacokinetic study of galantamine hydrobromide 8 mg prolonged-release capsules. The plasma sample was prepared by simple
Darunee Hongwiset, Songwut Yotsawimonwat, Chokchai Wongsinsup, Saowarunee Sangsrijan, Chuleegone Sornsuvit   +4 more
doaj   +1 more source

Alzheimer’s disease: clinical management errors

Медицинский совет, 2020
The management of patients with Alzheimer’s disease (AD) is one of the urgent problems of modern medicine, however, not only general practitioners, but also neurologists in our country are not sufficiently aware of modern methods of AD therapy, which ...
V. A. Parfenov
doaj   +1 more source

Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory [PDF]

, 2016
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ...
Albertini, Giulia, De Bundel, Dimitri, Leybaert, Luc, Smolders, Ilse J., Vinken, Mathieu, Walrave, Laura   +5 more
core   +2 more sources

Catecholamine-Based Treatment in AD Patients: Expectations and Delusions. [PDF]

, 2015
In Alzheimer disease, the gap between excellence of diagnostics and efficacy of therapy is wide. Despite sophisticated imaging and biochemical markers, the efficacy of available therapeutic options is limited.
Alessandro eStefani, Alessandro eStefani, Atticus H Hainsworth, Claudio eLiguori, Enrica eOlivola, Giacoma eAngileri, Mariangela ePierantozzi, Salvatore eGalati, Valentina eSaviozzi, Vincenza eD’Angelo   +9 more
core   +3 more sources