Results 61 to 70 of about 18,363 (193)

Wake‐promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSS) regulate arousal, cognition, and sleep–wake transitions through widespread influence on cortical and subcortical networks. Increasing evidence links dysfunction of these systems to the pathogenesis of Alzheimer's disease (AD). Degeneration and dysregulation of NSS occurs during the preclinical phase of
Taylor J. Pedersen, Sabrina G. Clemens, Joseph R. Winer, Ashish Sharma, Neus Falgàs, Brendan P. Lucey, Brian A. Gordon, Erik S. Musiek   +7 more
wiley   +1 more source

Cognitive dysfunction and dementia in Parkinson's disease [PDF]

, 2004
Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder mainly characterized by degeneration of dopaminergic neurons in the substantia nigra and the ventral tegmental area, in combination with a varying loss of central noradrenergic ...
Bosboom, JL, Stoffers, D., Wolters, E.C.M.J.   +2 more
core   +1 more source

Preparation and Release Profiles in Vitro/Vivo of Galantamine Pamoate Loaded Poly (Lactideco-Glycolide) (PLGA) Microspheres

Frontiers in Pharmacology, 2021
Patient’s poor compliance and the high risk of toxic effects limit the clinical use of galantamine hydrobromide. To overcome these drawbacks, the sustained-release galantamine pamoate microspheres (GLT-PM-MS) were successfully developed using an oil ...
Liping Du, Shankui Liu, Guizhou Hao, Li Zhang, Miaomiao Zhou, Yueqing Bao, Bing Ding, Qinyong Sun, Guimin Zhang   +8 more
doaj   +1 more source

Astragalus Polysaccharides Can Effectively Alleviate Cognitive Impairment in Mice With Alzheimer's Disease by Regulating the Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This schematic diagram illustrates that Astragalus polysaccharides improve cognitive dysfunction in 3xTg AD mice by regulating the gut‐brain axis. APS ameliorates gut microbiota and enhances intestinal barrier function, thereby reducing systemic and central inflammation, inhibiting microglial overactivation, and alleviating Aβ deposition and Tau ...
Xilian Wang, Xinyun Ge, Xin Di, Zhiyan Zou, Dan Lei, Zihao Wang, Jiaqiang Hou, Yan Yang, Wanxue Zhang, Yuan Yin, Xinnuo Lei, Yu Long, Xuemin Jian, Xiaoan Li   +13 more
wiley   +1 more source

Multitarget drug design strategy in Alzheimer’s disease: focus on cholinergic transmission and amyloid-β aggregation [PDF]

, 2017
Background: Alzheimer pathogenesis has been associated with a network of processes working simultaneously and synergistically. Over time, much interest has been focused on cholinergic transmission and its mutual interconnections with other active players
Abu, Izuddin F., Andrisano, Vincenza, Bartolini, Manuela, Bergamini, Christian, Blockley, Alix, Bottegoni, Giovanni, Caporaso, Roberta, Cavalli, Andrea, Gotti, Cecilia, Mellor, Ian R., Minarini, Anna, Rosini, Michela, Simoni, Elena   +12 more
core   +2 more sources

Pyrazoline Derivatives: Synthesis, In Silico, Enzyme Kinetics Studies and Biological Activity against Cholinesterase, Lipoxygenase, and α‐Amylase

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Nucleophilic cyclization of the α, β‐unsaturated carbonyl framework of the prepared (E)‐4‐(3‐bromo‐4‐hydroxy‐5‐methoxyphenyl)but‐3‐en‐2‐one with various hydrazine derivatives to afford their corresponding pyrazolines has been achieved. The enzyme assays conducted showed significant α‐amylase inhibitory activity for 4b with IC50 value of 2.7 µM.
Redolf S. Segodi, E. N. Agbo, Leoma B. Mofeli, K. W. Poopedi, O. O. Oderinlo, W. Nxumalo   +5 more
wiley   +1 more source

Family Caregiver Burden and Neuropsychiatric Symptoms in Japanese Community‐Dwelling People With Alzheimer's Disease: A Cross‐Sectional Study Using a Web‐Based Questionnaire

Psychogeriatrics, Volume 26, Issue 2, March 2026.
ABSTRACT Background Previous studies of community‐dwelling people with Alzheimer's disease (AD) have reported an association between the severe neuropsychiatric symptoms (NPS) of dementia and caregiver burden. We explored the current status of family caregiver burden, NPS of dementia, and care service usage in Japanese community‐dwelling people with AD.
Tomoyuki Nagata, Shunichiro Shinagawa, Shinichi Noto, Kentaro Yamato, Naoki Mori, Keisuke Onuki   +5 more
wiley   +1 more source

Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice

Journal of Neuroinflammation, 2018
Background Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases such as Alzheimer’s disease. Lipopolysaccharide (LPS, endotoxin) levels are higher in the brains of Alzheimer’s disease patients and are ...
Yi Liu, Yuyun Zhang, Xian Zheng, Tongyong Fang, Xia Yang, Xuan Luo, Anlei Guo, Kelly A. Newell, Xu-Feng Huang, Yinghua Yu   +9 more
doaj   +1 more source

The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real‐world data

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Given the complexity of dementia, the inconsistent evidence on statins and dementia highlights the need for robust methods to assess heterogeneous treatment effects (HTEs). METHODS We emulated a target trial using UK Biobank comparing statin initiators and non‐initiators aged ≥55 years.
Yongjie Lai, Qoua L Her, Yue Zhang, Hong Xu, Anna Kucharska‐Newton, Dongze Ji, Guorong Wu, Gwenn Garden, Til Stürmer, Tiansheng Wang, Yang Xu   +10 more
wiley   +1 more source

Donepezil Research in Cognitive Impairment: A Bibliometric and Scientometric Analysis of Global Trends and Pharmacological Perspectives

Brain and Behavior, Volume 16, Issue 2, February 2026.
Donepezil research in cognitive impairment: a bibliometric and scientometric analysis. ABSTRACT Background Cognitive impairment (CI) greatly affects global health and quality of life. Donepezil, a widely used treatment for CI, particularly in Alzheimer's disease, has been extensively studied; however, a comprehensive bibliometric analysis summarizing ...
Wencai Wang, Yinuo Chen, Zijie Xiong, Zun Wang, Wei Ye, Xianfeng Li   +5 more
wiley   +1 more source