Results 71 to 80 of about 18,363 (193)

Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors. [PDF]

, 2010
Background: This study examines the joint effect on cognition of selective serotonin re-uptake inhibitors (SSRIs) and cholinesterase inhibitors (AChEIs) in depressed patients affected by Alzheimer’s disease (AD) living at home.
Bertoletti E, Conti M, Padovani A., Rozzini L., Trabucchi M, Vicini Chilovi B., Zanetti M   +6 more
core   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Navigating the Chemical Space of Multitarget-Directed Ligands:From Hybrids to Fragments in Alzheimer's Disease [PDF]

, 2016
Multitarget drug discovery is one of the hottest topics and most active fields in the search for new molecules against Alzheimer’s disease (AD). Over the last 20 years, many promising multitarget-directed ligands (MTDLs) have been identified and ...
Andrea Cavalli, Federica Prati, Maria Bolognesi, Morphy   +3 more
core   +3 more sources

Movement disorders associated with acetylcholinesterase inhibitors in Alzheimer’s dementia: A systematic review

Brain Circulation
BACKGROUND: Acetylcholinesterase inhibitors (AChEIs) are widely used in Alzheimer’s disease (AD). This study aims to systematically review the literature about movement disorders (MDs) associated with AChEIs for AD, which include donepezil, galantamine ...
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara   +1 more
doaj   +1 more source

Comparative effectiveness of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists for incident dementia: A retrospective multicohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1443-1452, February 2026.
Abstract Objective This study provides real‐world evidence on the comparative effectiveness of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) regarding the risk of incident dementia in adults with type 2 diabetes mellitus (T2DM).
Filippos Anagnostakis, Michail Kokkorakis, Shrihari Nagarajan, Georgia Anastasiou, Christos S. Mantzoros   +4 more
wiley   +1 more source

Galantamine-Memantine Combination in the Treatment of Parkinson’s Disease Dementia

Brain Sciences
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 1% of population over age 60. It is defined by motor and nonmotor symptoms including a spectrum of cognitive impairments known as Parkinson’s disease dementia (PDD ...
Emma D. Frost, Swanny X. Shi, Vishnu V. Byroju, Jamir Pitton Rissardo, Jack Donlon, Nicholas Vigilante, Briana P. Murray, Ian M. Walker, Andrew McGarry, Thomas N. Ferraro, Khalid A. Hanafy, Valentina Echeverria, Ludmil Mitrev, Mitchel A. Kling, Balaji Krishnaiah, David B. Lovejoy, Shafiqur Rahman, Trevor W. Stone, Maju Mathew Koola   +18 more
doaj   +1 more source

Association between basal forebrain volume and age in the presenilin‐1 E280A autosomal dominant Alzheimer's disease kindred

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The basal forebrain (BF), a key cholinergic hub, undergoes atrophy in Alzheimer's disease (AD), contributing to cognitive decline. However, its age‐related differences and early vulnerability in autosomal dominant AD (ADAD) remain unclear.
Bing He, Paula Ospina Lopera, Alejandro Espinosa, Juan Camilo Becerra, Laura Osorio, Diana Alzate, Sergio Alvarez, Alice Grazia, Stefan J. Teipel, Vincent Malotaux, Catarina Tristão‐Pereira, Meredith C. Rowe, Averi Giudicessi, Yi Su, Yinghua Chen, Sonia Do Carmo, David Aguillón, A. Claudio Cuello, Yakeel T. Quiroz   +18 more
wiley   +1 more source

The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial [PDF]

, 2017
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a group of psychological reactions, psychiatric symptoms, and behaviors commonly found in Alzheimer's disease (AD).
Amenta, Francesco, Carotenuto, Anna, Fasanaro, Am, Manzo, V, Rea, Raffaele, Ricci, Giovanna, Traini, Enea   +6 more
core   +1 more source

Transcriptome Analysis and Metabolic Profiling of Lycoris Radiata

Biology, 2019
Lycoris radiata belongs to the Amaryllidaceae family and is a bulbous plant native to South Korea, China, and Japan. Galantamine, a representative alkaloid of Amaryllidaceae plants, including L.
Chang Ha Park, Hyeon Ji Yeo, Ye Eun Park, Seung-A Baek, Jae Kwang Kim, Sang Un Park   +5 more
doaj   +1 more source

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source