Results 81 to 90 of about 23,209 (275)
Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1443-1452, February 2026.Abstract Objective This study provides real‐world evidence on the comparative effectiveness of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) regarding the risk of incident dementia in adults with type 2 diabetes mellitus (T2DM).
Filippos Anagnostakis +4 more
wiley +1 more source
Treating disorders across the lifespan by modulating cholinergic signaling with galantamine
Journal of Neurochemistry, 2020 Advances in understanding the regulatory functions of the nervous system have revealed neural cholinergic signaling as a key regulator of cytokine responses and inflammation.
C. Metz, V. Pavlov
semanticscholar +1 more source
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION The basal forebrain (BF), a key cholinergic hub, undergoes atrophy in Alzheimer's disease (AD), contributing to cognitive decline. However, its age‐related differences and early vulnerability in autosomal dominant AD (ADAD) remain unclear.
Bing He +18 more
wiley +1 more source
The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial [PDF]
, 2017 BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a group of psychological reactions, psychiatric symptoms, and behaviors commonly found in Alzheimer's disease (AD).
Amenta, Francesco +6 more
core +1 more source
Archiv der Pharmazie, Volume 359, Issue 1, January 2026.Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová +9 more
wiley +1 more source
Galantamine as a Treatment Option for Nicotine Addiction
Journal of Smoking Cessation, 2021 The pharmacological therapy for smoking cessation recommended by National Institute for Health and care Excellence (NICE) guidelines is nicotine replacement therapy such as gum, inhalator, lozenge, nasal spray, oral spray, sublingual tablet, and ...
Qutub Jamali
semanticscholar +1 more source
Alzheimer's disease - a review of medicinal substances and their derivatives [PDF]
Farmacja PolskaAlzheimer’s disease (AD) is a neurodegenerative disorder. Although the first case of Alzheimer’s disease was recorded over a century ago, the etiology of the disease remains unknown. There are several hypotheses regarding the process of neurodegeneration,
Marika Więcek +3 more
doaj +1 more source
Navigating the Chemical Space of Multitarget-Directed Ligands:From Hybrids to Fragments in Alzheimer's Disease [PDF]
, 2016 Multitarget drug discovery is one of the hottest topics and most active fields in the search for new molecules against Alzheimer’s disease (AD). Over the last 20 years, many promising multitarget-directed ligands (MTDLs) have been identified and ...
Andrea Cavalli +3 more
core +3 more sources
Brain and Behavior, Volume 16, Issue 1, January 2026.An overview of the mechanism of action, clinical trials, and classical findings of KarXT for the management of psychotic symptoms in patients with schizophrenia and alzheimer's disease. ABSTRACT Background Acute psychotic symptoms like delusions and hallucinations are of major concern while treating patients with schizophrenia and alzheimer's psychosis,
Ashir Kanwal +7 more
wiley +1 more source
Thiol-reactive analogues of galanthamine, codeine and morphine as potential probes to interrogate allosteric binding within nAChRs [PDF]
, 2016 Alkaloids including galanthamine (1) and codeine (2) are reported to be positive allosteric modulators of nicotinic acetylcholine receptors (nAChRs) but the binding sites responsible for this activity are not known with certainty.
Balle, Thomas +3 more
core +1 more source