Results 81 to 90 of about 20,091 (201)

Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods

open access: yesFood Frontiers, Volume 6, Issue 3, Page 1376-1408, May 2025.
In this study, we showed the potential therapeutical properties, namely, antioxidant, antimicrobial, enzyme inhibitory, and antitumor, of Liquidambar orientalis extracts from its aerial parts using methanol, ethyl acetate, and water. The methanolic extract of exhibited the highest phenolic and flavonoid content, demonstrating superior antioxidant ...
Mehmet Cengiz Baloglu   +9 more
wiley   +1 more source

X-ray crystalographic data, absolute configuration, and anticholinesterase effect of dihydromyricitrin 3-O-rhamnoside

open access: yesScientific Reports, 2022
Based on our continuous effort to investigate chemistry and biology of the plant secondary metabolites, we were able to isolate a glycosidal flavonoid 1 from the Wild Egyptian Artichoke.
Mahmoud Fahmi Elsebai   +4 more
doaj   +1 more source

Ultrasound‐Assisted Extraction of Bioactive Compounds From Black Pine (Pinus nigra) Bark: Optimization and Evaluation of Their In Vitro Bioactivities

open access: yesFood Science &Nutrition, Volume 13, Issue 5, May 2025.
Black pine bark extract holds significant potential as a versatile bioactive ingredient for the development of functional foods. Its antioxidant, antidiabetic, and health promoting properties make it valuable for enhancing the nutritional and functional quality of food products. Its incorporation into foods can also enhance their nutritional properties 
Kubra Feyza Erol   +3 more
wiley   +1 more source

Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]

open access: yes, 2017
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos   +11 more
core   +3 more sources

Opening New Roads for Multi‐Directional Functional Applications Through In Vitro Chemical and Biological Analysis of Zoegea leptaurea L. Extracts

open access: yesFood Science &Nutrition, Volume 13, Issue 5, May 2025.
Zoegea leptaurea is a promising source of bioactive compounds and warrants further investigation for its potential role in the treatment of global health problems. ABSTRACT Zoegea leptaurea L. has been traditionally used to treat digestive issues, headaches, and skin diseases.
Sakina Yagi   +12 more
wiley   +1 more source

Chemical Constituents and Biological Activities of Strobilanthes crispus L. [PDF]

open access: yes, 2013
Phytochemical investigation of Strobilanthes crispus has led to the isolation of 1-heptacosanol (1), tetracosanoic acid (2), stigmasterol (3) from the hexane extract, a mixture of four C20-C24 fatty acid esters of - amyrin (4), taraxerol (5 ...
Asmawi, Mohammad Zaini   +4 more
core  

Investigation of Thiazolidine‐2,4‐Dione Derivatives as Acetylcholinesterase Inhibitors: Synthesis, In Vitro Biological Activities and In Silico Studies

open access: yesChemistryOpen, Volume 14, Issue 5, May 2025.
Thiazolidin‐2,4‐dion derivatives were synthesized and evaluated for drug‐likeness, BBB permeability, and ADMET properties. Docking studies revealed that all derivatives (CHT1‐5) had good AChE inhibition, although CHT1 was the most effective and showed strong antioxidant activity in vitro.
Hanane Naeimi   +3 more
wiley   +1 more source

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease [PDF]

open access: yes, 2013
This review describes the preclinical mechanisms that may underlie the increased therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor antagonist, memantine, and an acetylcholinesterase inhibitor (AChEI)—for the treatment of ...
Andrzej Dekundy   +3 more
core   +1 more source

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(−) Enantiomers in Rett Syndrome

open access: yesJournal of Neurochemistry, Volume 169, Issue 5, May 2025.
Computational pipeline to identify potential drug targets and pathways for Rett syndrome, by analyzing ligand‐bound pockets and predicted drug affinities. ABSTRACT Rett syndrome (RTT) is a progressive neurodevelopmental disorder that affects approximately 1:10000 newborn girls and is primarily caused by mutations in the X‐linked gene MECP2.
Ottavia Maria Roggero   +5 more
wiley   +1 more source

Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L. [PDF]

open access: yes, 2010
The whole plant extract of plant Sceletium tortuosum, plant native to South Africa, has been known traditionally to have mood enhancing and stimulant properties. These properties have been confirmed before by proving serotonin-uptake inhibition activity.
Khatib, Alfi   +4 more
core  

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