Results 1 to 10 of about 15,607 (129)

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation [PDF]

Nature Communications, 2019
Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and ...
Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, Emad S. Alnemri   +5 more
doaj   +4 more sources

Gasdermin E (GSDME)—A New Potential Marker of Psoriasis and Its Metabolic Complications: The First Combined Study on Human Serum, Urine and Tissue [PDF]

Cells, 2023
Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska, Anna Baran, Anna Pryczynicz, Justyna Magdalena Hermanowicz, Beata Sieklucka, Dariusz Pawlak, Iwona Flisiak   +6 more
doaj   +2 more sources

Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores [PDF]

iScience, 2023
Summary: Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate ...
Coralie Guy, Marcin Baran, Pau Ribó-Molina, Bernadette G. van den Hoogen, Andrew G. Bowie   +4 more
doaj   +2 more sources

Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice [PDF]

Microbiology Spectrum
Targeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in ...
Samuel Speaks, Jonathan Papa, Matthew McFadden, Jack E. Roettger, Benjamin D. Liu, Shreenath Mohan, Brendan M. Reznik, Steve Leumi, Jana M. Cable, Adriana Forero, Jacob S. Yount   +10 more
doaj   +2 more sources

Protection against post-resuscitation renal injury by Artesunate via inhibition of caspase-3/Gasdermin E -mediated pyroptosis [PDF]

Resuscitation Plus
Background: Post-resuscitation renal injury is the common complication after cardiac arrest and resuscitation. Artesunate (Art) has been confirmed to protect against regional ischemia–reperfusion injuries in multiple organs. This study aimed to determine
Qianqian Wang, Peng Shen, Wang Wu, Jiangang Zhu, Jiefeng Xu   +4 more
doaj   +2 more sources

Gasdermin E: A Prospective Target for Therapy of Diseases [PDF]

Frontiers in Pharmacology, 2022
Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells
Xiu-Xiu Liao, Yong-Zhao Dai, Yao-Zhong Zhao, Ke Nie   +3 more
doaj   +2 more sources

Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts [PDF]

Life Science Alliance, 2023
Disruption of atypical protein kinase-C isoforms leads to the initiation of pyroptosis, a form of programmed necrosis, in placental syncytiotrophoblasts at the human maternal–fetal interface.
Khushali Patel, Jasmine Nguyen, Sumaiyah Shaha, Amy Brightwell, Wendy Duan, Ashley Zubkowski, Ivan K Domingo, Meghan Riddell   +7 more
doaj   +2 more sources

Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity [PDF]

Nature Communications, 2023
Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell ...
Jing Lin, Shihui Sun, Kui Zhao, Fei Gao, Renling Wang, Qi Li, Yanlong Zhou, Jing Zhang, Yue Li, Xinyue Wang, Le Du, Shuai Wang, Zi Li, Huijun Lu, Yungang Lan, Deguang Song, Wei Guo, Yujia Chen, Feng Gao, Yicheng Zhao, Rongrong Fan, Jiyu Guan, Wenqi He   +22 more
doaj   +2 more sources

Gasdermin E in glioblastoma –pyroptosis resistance and tumor-promoting functions [PDF]

Cell Death Discovery
Treatment of glioblastoma (GB), the most common and most aggressive malignant brain tumor, has made little progress over the past two decades. Despite extensive research on apoptosis and autophagy, necrotic cell death mechanisms like pyroptosis, which ...
Ege Solel, Egil Brudvik, Lars Andreas Rømo Ystaas, Yahaya A. Yabo, Emma Rigg, Romi Roy Choudhury, Halala Sdik Saed, Dieter Henrik Heiland, Rolf Bjerkvig, Jubayer Hossain, Hrvoje Miletic   +10 more
doaj   +2 more sources

Methylcobalamin protects against liver failure via engaging gasdermin E [PDF]

Nature Communications
Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific
Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao   +14 more
doaj   +2 more sources