BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer [PDF]
Frontiers in Oncology, 2022 BackgroundThe frequent emergence of drug resistance to chemotherapy is a major obstacle for the treatment of ovarian cancer. There is a need for novel drugs to fulfill this challenge. Pyroptosis-inducing drugs can inhibit tumor growth.
Jianting Huo +5 more
doaj +4 more sources
Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases [PDF]
Cell Reports, 2021 Summary: Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release.
Bowen Zhou, Derek W. Abbott
doaj +5 more sources
Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E [PDF]
VirusesHuman coronavirus 229E (HCoV-229E) is associated with upper respiratory tract infections and generally causes mild respiratory symptoms. HCoV-229E infection can cause cell death, but the molecular pathways that lead to virus-induced cell death as well as
Xavier Martiáñez-Vendrell +5 more
doaj +5 more sources
Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Nature, 2020 Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-expressing cells3-5. GSDME expression
Zhang, Zhibin +13 more
openaire +6 more sources
Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis [PDF]
Frontiers in Oncology, 2021 Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up
Zheng Zhang +6 more
doaj +3 more sources
Cell Reports, 2021 Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan +4 more
doaj +3 more sources
Neobractatin and Trametinib Synergistically Induce Apoptosis and Gasdermin E‐Dependent Pyroptosis in Pancreatic Cancer Cells [PDF]
MedCommMutations in mitogen‐activated protein kinase kinase (MEK) are prevalent in pancreatic ductal adenocarcinoma (PDAC), but many MEK inhibitors inadvertently activate protein kinase B (AKT).
Jiaqi Tan +7 more
doaj +2 more sources
Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection [PDF]
Cell Death and DiseaseSevere influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli +9 more
doaj +2 more sources
Targeting gasdermin E in neurodegenerative diseases. [PDF]
Cell Rep Med, 2023 Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
Zhou ZD, Yi LX, Tan EK.
europepmc +3 more sources
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation [PDF]
Nature CommunicationsImmune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear.
Si-Jia Sun +17 more
doaj +2 more sources