Results 21 to 30 of about 15,677 (174)

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PDF]

Neuron, 2023
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood. Here, we find that one GSDM family member, GSDME, is expressed by both mouse and human neurons. GSDME plays a
Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM.   +22 more
europepmc   +3 more sources

Gasdermin D and Gasdermin E Are Dispensable for Silica-Mediated IL-1β Secretion from Mouse Macrophages. [PDF]

Immunohorizons
Abstract Silica crystals activate the NLRP3 inflammasome in macrophages, resulting in the caspase-1–dependent secretion of the proinflammatory cytokine IL-1β. Caspase-1–mediated cleavage of gasdermin D (GSDMD) triggers the formation of GSDMD pores, which drive pyroptotic cell death and facilitate the rapid release of IL-1β.
Leung J, Chang M, Moore RE, Dagvadorj J, Sutterwala FS, Cassel SL.   +5 more
europepmc   +3 more sources

Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response

Genes and Diseases, 2023
Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes
Wenchang Yang, Yaxin Wang, Tao Wang, Chengguo Li, Liang Shi, Peng Zhang, Yuping Yin, Kaixiong Tao, Ruidong Li   +8 more
doaj   +1 more source

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

BMC Biology, 2022
Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C. Baños, Jack Rivers-Auty, Pablo Pelegrín   +5 more
doaj   +1 more source

Irradiation Induces Gasdermin E-Triggered Tumor Immunity to Inhibit Esophageal Carcinoma Cell Survival. [PDF]

ACS Omega, 2023
Gasdermin E (GSDME), an executor of pyroptosis, can be activated by caspase-3 and has been recognized as a tumor suppressor in various human cancers. In addition, caspase-3/GSDME signal-induced pyroptosis is a form of immunogenic cell death (ICD). In this study, we aimed to understand the association between radiotherapy and caspase-3/GSDME signal ...
Tan B, Wang N, Yang S, Liu H, Cheng Y.
europepmc   +4 more sources

Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells [PDF]

Translational Cancer Research, 2020
Arsenic trioxide (ATO) has been proved useful for the treatment of acute promyelocytic leukemia (APL). Apoptosis is the result of the cytotoxic effect of ATO, apoptotic mediated cell death confirmed by DNA fragmentation and Annexin V staining. Although signaling associated with ATO-induced apoptosis has been well defined, it is still unknown whether ...
Wang, Jingling, Zhan, Linghui, Cai, Zheng, Liu, Xiaomei, Wang, Junsheng, Zhong, Huarong, Huang, Xianwei, Lai, Qinxiao, Tan, Qingzhao, Xiu, Yibin, Yang, Daowei, Min, Xianghui   +11 more
openaire   +2 more sources

Pyroptosis, inflammasome, and gasdermins in tumor immunity

Innate Immunity, 2023
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang, Junfen Zhou, Lan Lin, Zili Zhang, Shanshan Luo, Desheng Hu   +5 more
doaj   +1 more source

Gasdermin E-mediated intestinal epithelial pyroptosis promotes chemically induced colitis in mice. [PDF]

Gastroenterol Rep (Oxf)
Abstract Background Gasdermin E (GSDME) is a newly identified pyroptosis executioner and is upregulated in the intestinal epithelial cell (IEC) of ulcerative colitis (UC) patients. However, the effects of epithelial GSDME on UC remain unknown. Methods
Wu YZ, Xie Y, Chen L, Ning L, Hu XQ, Xu XP.   +5 more
europepmc   +3 more sources

PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage. [PDF]

Biochem Biophys Res Commun, 2023
The identification of PARP1 as a therapeutic target for BRCA1/2-deficient cells has led to a paradigm shift for the treatment of human malignancies with BRCA1/2 mutations. However, our understanding of the mechanism of action of PARP1 inhibitors (PARPi) is still evolving.
Kim C, Wang XD, Jang S, Yu Y.
europepmc   +3 more sources

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome [PDF]

, 2020
Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome ...
Atmosukarto, Ines I., Burgio, Gaetan, Feng, Shouya, Fox, Daniel, Fox, Edward M., Hayward, Jenni A., Jessberger, Nadja, Johnson, Matthew D., Kaakoush, Nadeem O., Leppla, Stephen H., Leyton, Denisse L., Liu, Yunqi, Man, Si Ming, Mathur, Anukriti, Märtlbauer, Erwin, Ngo, Chinh, Pandey, Abhimanu, Price, Jason D., Robertson, Avril A. B., Tan, Wei Hong, Tscharke, David C., Xue, Yansong   +21 more
core   +5 more sources