Results 101 to 110 of about 175,164 (279)

Genomic and phenotypic analysis of Vavilov's historic landraces reveals the impact of environment and genomic islands of agronomic traits. [PDF]

, 2017
The Vavilov Institute of Plant Genetic Resources (VIR), in St. Petersburg, Russia, houses a unique genebank, with historical collections of landraces.
Bulyntsev, Sergey, Carrasquilla-Garcia, Noelia, Chang, Peter L, Cook, Douglas R, Negash, Kassaye, Noujdina, Nina, Nuzhdin, Sergey V, Plekhanova, Elena, Samsonova, Maria G, Vishnyakova, Margarita A, Wettberg, Eric von   +10 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Breeding Low Emitting Ruminants: Predicting Methane from Microbes

Proceedings, 2020
The greatest source of global anthropogenic methane (CH4) emissions is from ruminant livestock. Multiple mitigation strategies in livestock are currently being explored.
Suzanne J. Rowe, Melanie Hess, Larissa Zetouni, Sharon Hickey, Rudiger Brauning, Hannah Henry, Holly Flay, Juliana Budel, Brooke Bryson, Peter Janssen, Arjan Jonker, John McEwan   +11 more
doaj   +1 more source

Genome wide SNP discovery in flax through next generation sequencing of reduced representation libraries [PDF]

, 2012
BACKGROUND: Flax (Linum usitatissimum L.) is a significant fibre and oilseed crop. Current flax molecular markers, including isozymes, RAPDs, AFLPs and SSRs are of limited use in the construction of high density linkage maps and for association mapping ...
Frank M You, Santosh Kumar, Sylvie Cloutier   +2 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

High Density Genetic Maps of Seashore Paspalum Using Genotyping-By-Sequencing and Their Relationship to The Sorghum Bicolor Genome. [PDF]

, 2019
As a step towards trait mapping in the halophyte seashore paspalum (Paspalum vaginatum Sw.), we developed an F1 mapping population from a cross between two genetically diverse and heterozygous accessions, 509022 and HI33.
Devos, Katrien M, Eudy, Douglas, Qi, Peng, Raymer, Paul L, Schmutz, Jeremy, Schnable, James C   +5 more
core  

High-resolution genetic map and QTL analysis of growth-related traits of Hevea brasiliensis cultivated under suboptimal temperature and humidity conditions [PDF]

, 2018
Rubber tree (Hevea brasiliensis) cultivation is the main source of natural rubber worldwide and has been extended to areas with suboptimal climates and lengthy drought periods; this transition affects growth and latex production.
André R. O. Conson, Anete P. de Souza, Anete P. de Souza, Antonio A. F. Garcia, Camila C. Mantello, Camila C. Mantello, Carla C. da Silva, Cristiane H. Taniguti, Erivaldo José Scaloppi Junior, Isabela A. A. Andreotti, João R. B. F. Rosa, João R. B. F. Rosa, Livia M. de Souza, Luciano H. B. dos Santos, Paulo de Souza Gonçalves, Rafael V. Ribeiro, Rodrigo R. Amadeu, Vincent Le Guen   +17 more
core   +3 more sources

Genotyping by Sequencing (GBS) library protocols v1 [PDF]

, 2017
Genotyping by sequencing (GBS) is a restriction enzyme based targeted approach developed to reduce the genome complexity and discover genetic markers when a priori sequence information is unavailable. Sufficient coverage at each locus is essential to distinguish heterozygous from homozygous sites accurately.
openaire   +1 more source