Results 221 to 230 of about 78,621 (245)
Some of the next articles are maybe not open access.
Astrocytic phospholipase A2 contributes to neuronal glutamate toxicity
Brain Research, 2014The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers.
Jong Seong Ha +4 more
openaire +2 more sources
Aripiprazole protects cortical neurons from glutamate toxicity
European Journal of Pharmacology, 2011Neurodegeneration is thought to be a component of schizophrenia pathology, and some antipsychotics appear to slow degenerative changes in patients. Aripiprazole, the first partial dopamine D(2) receptor agonist approved for the treatment of schizophrenia, is suggested to be neuroprotective based on non-clinical studies using transformed cell lines and ...
Vuk, Koprivica +7 more
openaire +2 more sources
Glutamate Toxicity in Lung and Airway Disease
20071. Experimental glutamate toxicity can occur in the respiratory system. Acute administration of high concentrations of glutamate or glutamate agonist NMDA can elicit high-permeability pulmonary edema and airway constriction. 2. Endogenous glutamate receptor activation may play a key role in mediating oxidant lung injury, and airway hyper-
openaire +1 more source
Glutamic acid modification of vincristine toxicity.
Cancer biochemistry biophysics, 1984The principal limiting feature of the antitumor agent, vincristine, in the clinic has been neurotoxicity; there are no known agents which can routinely prevent or decrease this side effect. Glutamic acid in laboratory and clinical investigations in the early 1960s was found to antagonize vinblastine, another clinically useful vinca alkaloid.
D V, Jackson +5 more
openaire +1 more source
In vitro evidence for the hole of glutamate in the CNS toxicity of mercury
Toxicology, 1992Intoxication with elemental mercury vapor or with methylmercury results in the accumulation of mercuric mercury (Hg2+) in the brain. Submicromolar concentrations of Hg2+ were shown previously to inhibit glutamate uptake in astrocyte cultures selectively and reversibly.
openaire +2 more sources
Glutamate in current paediatric amino acid solutions is not toxic
Acta Paediatrica, 2006Abstract Aim: To discuss the viewpoint article “How much glutamate is toxic in paediatric parenteral nutrition?” Acta Paediatr 2005;94;16–9.Conclusion: There is no doubt that glutamate used at high bolus doses in animal experiments would permanently damage brain cells.
openaire +2 more sources
Ionotropic glutamate receptors in lungs and airways: molecular basis for glutamate toxicity.
American journal of respiratory cell and molecular biology, 2004We earlier showed that the ionotropic glutamate receptor agonist N-methyl D-aspartate (NMDA) induces excitotoxic pulmonary edema, and that endogenous activation of NMDA receptors (NMDAR) could mediate lung injury caused by oxidative stress. In this study, we searched for evidence of NMDAR expression in the rat lung and in the alveolar macrophage (AM ...
Kathleen G, Dickman +3 more
openaire +1 more source
THE TOXIC EFFECTS OF GLUTAMATE AND RELATED COMPOUNDS IN THE RETINA AND THE BRAIN
Retina, 1982This paper has reviewed information pertaining to an interesting group of amino acids--glutamate, aspartate, and certain of their structural analogs, some of which are neurotransmitter candidates, and all of which have both neuroexcitatory and neurotoxic activities.
openaire +2 more sources
Glutamate alleviates cadmium toxicity in rice via suppressing cadmium uptake and translocation
Journal of Hazardous Materials, 2020Shiyong Song, Yuanyuan Tan, Shan Li
exaly