Results 211 to 220 of about 78,621 (245)
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Neuropathology of aluminum toxicity in rats (glutamate and GABA impairment)
Pharmacological Research, 2003To get better insights into the pathological and biochemical defects underlying aluminum toxicity in brain tissue, we exposed male albino rats for 35 days to aluminum sulfate by gavage. Tissue aluminum level of brain was assessed, histological sections of brain were examined and amino acid transmitters contents were detected by reversed phase high ...
Sahar Ayad
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NONLINEAR EFFECTS OF GLUTAMATE AND KCl ON GLUTAMATE TOXICITY IN CULTURED RAT CEREBELLAR NEURONS
International Journal of Neuroscience, 2003Nonlinear responses to toxin exposure have been observed in multiple cell types and organisms across a wide array of phyla. High dose toxin exposures inhibit or kill biological systems, while low dose exposures can stimulate survival mechanisms. We examined the effects of low (10(-3), 10(-5), 10(-7), and 10(-9) M) and ultra-low (10(-25) and 10(-61) M ...
Diane, Marotta +4 more
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Analysis of glutamate uptake and monosodium glutamate toxicity in neural retina monolayer cultures
Developmental Brain Research, 1981Abstract Three different types of monolayer cultures from 8-day chick embryo neural retina can be generated by differential manipulation of culture media and substrata. They are: (i) a purified monolayer of neurons; (ii) a purified monolayer of nonneuronal, flat cells; and (iii) complex cultures containing both neurons and nonneurons ...
A G, Hyndman, R, Adler
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Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents
Developmental Brain Research, 1990Cationic fluxes resulting from glutamate receptor activity have recently been implicated in neurotoxicity. Immature cortical neurons are insensitive to the toxic effects of glutamate receptor stimulation. However, these neurons are killed by glutamate via a non-receptor-mediated mechanism thought to stem from glutamate's ability to inhibit cystine ...
T H, Murphy, J M, Baraban
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Scutellarin Attenuates Oxidative Glutamate Toxicity in PC12 Cells
Planta Medica, 2004The present study investigated the protective effects of the antioxidant scutellarin against oxidative toxicity induced by glutamate in PC12 cells. Vitamin E, a classical antioxidant was employed as a comparative agent. Incubation of PC12 cells with 10 mM glutamate resulted in significant cytotoxity as evaluated by the MTT and lactate dehydrogenase ...
Guo-Qing Liu
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Cysteine, Sulfite, and Glutamate Toxicity: A Cause of ALS?
The Journal of Alternative and Complementary Medicine, 2008Amyotrophic lateral sclerosis (ALS) of nonmutant superoxide dismutase (SOD) type may be caused by toxicity of the reduced glutathione (GSH) precursors glutamate and cysteine, and sulfite (a metabolite of cysteine), which accumulate when one or more of the enzymes needed for GSH synthesis are defective.A case is examined where the patient exhibited ...
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Manganese Toxicity and the Glutamine–Glutamate Cycle
2014Glutamine (Gln) is abundantly expressed in the central nervous system (CNS), where it participates in a variety of metabolic pathways. Gln metabolism proceeds via the glutamine/glutamate (Glu)-γ-aminobutyric acid (GABA) cycle (GGC), and the reactions within this cycle are carried out both in astrocytic and neuronal compartments. The GGC appears to have
Marta Sidoryk-Wegrzynowicz +1 more
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Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity
Brain Research, 2010Oxidative glutamate toxicity is characterized by the inhibition of cystine uptake, the depletion of intracellular glutathione, and increased levels of intracellular reactive oxygen species, factors that lead to neuronal injury. We found that the presence of extracellular catalase protected cultured neuronal cells, such as HT22, SH-SY5Y and PC12 cells ...
Jong Seong, Ha +2 more
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Protection by prostaglandins from glutamate toxicity in cortical neurons☆
Neurochemistry International, 1994The growing evidence that glutamate may be an important agent mediating ischemic damage to neurons, led us to investigate the possible protective effects of pharmacological agents against glutamate in a model system of cortical neurons. In this study we examined, in particular, the cytoprotective effect of prostaglandins.
C, Cazevieille +4 more
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Proteomic analysis of glutamate‐induced toxicity in HT22 cells
PROTEOMICS, 2007AbstractIn the present study, we have investigated the proteome changes associated with glutamate‐induced HT22 cell death, a model system to study oxidative stress‐mediated toxicity. Among a number of HT22 proteins exhibiting altered expression, several molecular chaperones demonstrated substantial changes.
Youra, Lee +6 more
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