Results 201 to 210 of about 78,621 (245)

The toxicity of monosodium glutamate in young rats

Biochimica et Biophysica Acta (BBA) - General Subjects, 1971
Abstract Intraperitoneal or intragastric injection of monosodium l -glutamate (4 mg/g) to infant rats invariably caused an increase in brain glutamine, never in brain glutamate. The toxicity (convulsions) observed after these doses was not unique to l -glutamate; monosodium l -aspartate or d -glutamate gave similar symptoms.
I K, Mushahwar, R E, Koeppe
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Neuroprotection from glutamate toxicity with ultra-low dose glutamate

Neuroreport, 2001
The protective effects of ultra-low doses (ULD) of glutamate against glutamate toxicity was studied in primary rat spinal, cortical and cerebellar neurons. Neurons were exposed to four subtoxic, ultra-low concentrations of glutamate (10(-18) M, 10(-20)M, 10(-22) M and 10(-30) M) for 72 h and then subsequently challenged with toxic concentrations (25 ...
W, Jonas, Y, Lin, F, Tortella
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Chronic glutamate toxicity in mouse cortical neuron culture

Brain Research, 2009
Two pathways for glutamate toxicity have been described, receptor-mediated excitotoxicity and non-receptor mediated oxidative glutamate toxicity. Here, we show that two distinct forms of receptor-mediated primary cortical neuronal death exist, chronic and acute glutamate toxicity, and that these depend on exposure time.
Jong Seong Ha
exaly   +3 more sources

Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
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Glutamate–pyruvate transaminase protects against glutamate toxicity in hippocampal slices

Brain Research, 2003
Elimination of glutamate through enzymatic degradation is an alternative to glutamate receptor blockade in preventing excitotoxic neuronal injury. Glutamate pyruvate transaminase (GPT) is a highly active glutamate degrading enzyme that requires pyruvate as a co-substrate.
C C, Matthews, H R, Zielke, D A, Parks, P S, Fishman   +3 more
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Management of monosodium glutamate toxicity

Journal of Asthma, 1982
(1982). Management of monosodium glutamate toxicity. Journal of Asthma: Vol. 19, No. 2, pp. 105-110.
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L-Glutamate toxicity in Huntington's Disease fibroblasts

Biochemical and Biophysical Research Communications, 1980
Abstract Brain degeneration in Huntington's Disease is thought to occur primarily in the regions of high L-glutamate concentrations. Huntington's Disease fibroblast cultures have a sensitivity to these high concentrations of L-glutamate. These cells show degeneration and loss of viability, within 12 hrs, following treatment with 30 mM L-glutamate ...
P N, Gray, P C, May, L, Mundy, J, Elkins
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Glutamate receptor-induced toxicity in neostriatal cells

Brain Research, 1996
Infrared differential interference contrast (IR DIC) videomicroscopy was used to measure and characterize cell swelling induced by activation of glutamate receptors (GluR) in a neostriatal brain slice preparation. This swelling is, in many cases, a prelude to necrotic cell death.
C S, Colwell, M S, Levine
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Age-dependent effects of glutamate toxicity in the hippocampus

Developmental Brain Research, 1996
While prolonged seizures can cause brain damage at any age, the extent of brain damage following prolonged seizures is highly age-dependent. Seizures in the immature brain are followed by far less histological damage than seizures of similar duration and intensity in mature animals. The reasons for this age-related phenomenon are unclear.
Z, Liu, C E, Stafstrom, M, Sarkisian, P, Tandon, Y, Yang, A, Hori, G L, Holmes   +6 more
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Calcium dynamics in neurons treated with toxic and non-toxic concentrations of glutamate

NeuroReport, 1992
Intracellular calcium concentration ([Ca2+]i) dynamics were simultaneously monitored in multiple cultured rat neurons loaded with Fluo-3 and continuously stimulated with glutamate (GLU). Three response types were observed: 10 microM GLU caused an initial transient increase in [Ca2+]i; 20 microM a biphasic response characterized by a 150-350 s 'calcium ...
M A, DeCoster, M L, Koenig, J C, Hunter, F C, Tortella   +3 more
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