Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond [PDF]
Frontiers in Physiology, 2014 Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Catheleyne eD'hondt +4 more
doaj +4 more sources
Extracellular cysteine in connexins: role as redox sensors [PDF]
Frontiers in Physiology, 2016 Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Mauricio Antonio Retamal +7 more
doaj +4 more sources
Frontiers in Cell and Developmental Biology, 2023 Bone adapts to changes in the physical environment by modulating remodeling through bone resorption and formation to maintain optimal bone mass. As the most abundant connexin subtype in bone tissue, connexin 43 (Cx43)-forming hemichannels are highly ...
Dezhi Zhao +6 more
doaj +2 more sources
Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens
Frontiers in Physiology, 2022 Connexins are a family of proteins that can form two distinct types of channels: hemichannels and gap junction channels. Hemichannels are composed of six connexin subunits and when open allow for exchanges between the cytoplasm and the extracellular ...
Mauricio A. Retamal +3 more
doaj +2 more sources
Mechano-activated connexin hemichannels mediate intercellular glutathione transport and support lens redox homeostasis [PDF]
Redox BiologyRedox homeostasis and transparency in the ocular lens are closely associated with the distribution of the antioxidant reduced glutathione (GSH).
Guangyan Wang +4 more
doaj +2 more sources
Role of astroglial hemichannels and pannexons in Memory and Neurodegenerative diseases [PDF]
Frontiers in Integrative Neuroscience, 2016 Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan Andrés Orellana +3 more
doaj +6 more sources
Pharmaceuticals, 2022 Inflammation mediators enhance the activity of connexin (Cx) hemichannels, especially in the epithelial and endothelial tissues. As potential release routes for injury signals, such as (oligo)nucleotides, Cx hemichannels may contribute to long-lasting ...
Anne Dierks +7 more
doaj +1 more source
Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory [PDF]
, 2016 Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ...
Albertini, Giulia +5 more
core +5 more sources
Divergence between Hemichannel and Gap Junction Permeabilities of Connexin 30 and 26
Life, 2023 Cx30 has been proposed to play physiological functions in the kidney and cochlea, and this has often been associated with its hemichannel role (deafness mutants frequently affecting hemichannels more than gap junctions), implicated in ATP release.
Ji Xu, Bruce J. Nicholson
doaj +1 more source
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes [PDF]
, 2014 In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct ...
Abudara, Verónica +8 more
core +8 more sources