Results 91 to 100 of about 15,174 (240)

Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes [PDF]

, 2017
Identifying mechanisms by which cells of the osteoblastic lineage communicate in vivo is complicated by the mineralised matrix that encases osteocytes, and thus, vital mechanoadaptive processes used to achieve load‐bearing integrity remain unresolved. We
Aarden, Ajubi, Alford, Bancroft, Batra, Bonewald, Brighton, Bruzzone, Burger, Burger, Burger, Chan, Cheng, Cheng, Cheng, Cheng, Cherian, Cherian, Chiba, Civitelli, Dallas, Damien, Damien, Davidson, Dietrich, Donahue, Doty, Endres, Frost, Genetos, Gluhak-Heinrich, Goldberg, Hasegawa, Heino, Iqbal, Irie, Javaheri, Javaheri, Jiang, Jones, Kamioka, Kato, Kleinnulend, Kulkarni, Lanyon, Nijweide, Osborne, Palumbo, Pitsillides, Rawlinson, Rawlinson, Rawlinson, Rawlinson, Rawlinson, Ren, Schirrmacher, Schwab, Shapiro, Siller-Jackson, Skerry, Skerry, Stanford, Su, Sugawara, Tan, Tanaka, Tanaka-Kamioka, Tatsumi, Taylor, Ulmann, Uzer, Van der Plas, Vazquez, Vezeridis, Weinbaum, Westbroek, Yamaguchi, Yang, Yellowley, You, Zaman, Zaman, Zhao, Ziambaras   +83 more
core   +3 more sources

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward, M. U. Shah, K. Lee, P. E. Squires, C. E. Hills   +4 more
wiley   +1 more source

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study [PDF]

, 2019
Purpose Even with an optimal treatment protocol, the median survival of glioblastoma (GB) patients is only 12-15 months. Hence, there is need for novel effective therapies that improve survival outcomes.
Bonte, Ellen, De Meulenaere, Valerie, De Wever, Olivier, Deblaere, Karel, Descamps, Benedicte, Goethals, Ingeborg, Kalala Okito, Jean-Pierre, Leybaert, Luc, Pieters, Leen, Vanhove, Christian, Verhoeven, Jeroen, Vral, Anne   +11 more
core   +1 more source

HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function

International Journal of Molecular Sciences, 2020
At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND).
Rosario Gajardo-Gómez, Cristian A. Santibáñez, Valeria C. Labra, Gonzalo I. Gómez, E. Eugenin, J. Orellana   +5 more
semanticscholar   +1 more source

Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice

MedComm, Volume 7, Issue 3, March 2026.
PGC‑1α downregulation in hippocampal astrocytes disrupts ATP release and reduces connexin 43 (CX43) expression, impairing neuro‑glial communication. This promotes enhanced fear memory retrieval in PTSD. Chemogenetic activation of astrocytes or PGC‑1α agonist treatment rescues both CX43 expression and fear behavior, identifying astrocytic PGC‑1α/CX43 as
Juan Wang, Xiaoyu Chen, Daokang Chen, Shaojie Yang, Jingji Wang, Ming Chen, Guoqi Zhu   +6 more
wiley   +1 more source

Connexin43 Hemichannel-Mediated Regulation of Connexin43

PLoS ONE, 2013
Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we ...
Kai Li, Yuan Chi, Kun Gao, Qiaojing Yan, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura, Jian Yao   +7 more
openaire   +4 more sources

Regulation of Connexin Gap Junctions and Hemichannels by Calcium and Calcium Binding Protein Calmodulin

International Journal of Molecular Sciences, 2020
Connexins are the structural components of gap junctions and hemichannels that mediate the communication and exchange of small molecules between cells, and between the intracellular and extracellular environment, respectively.
Zhengping Hu, M. Riquelme, S. Gu, Jean X. Jiang   +3 more
semanticscholar   +1 more source

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements, Julia Mesawich, Cassandra Twisdale   +2 more
wiley   +1 more source

Innexins: Expression, Regulation, and Functions

Frontiers in Physiology, 2018
The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes.
Juan Güiza, Iván Barría, Juan C. Sáez, Juan C. Sáez, José L. Vega   +4 more
doaj   +1 more source

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus, Dorota Frydecka, Michał Ślęzak   +2 more
wiley   +1 more source