Results 101 to 110 of about 15,174 (240)

Cardiac Connexin-43 Hemichannels and Pannexin1 Channels: Provocative Antiarrhythmic Targets

International Journal of Molecular Sciences, 2020
Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal caveolae/rafts compartments. GJCs are fundamental for the direct cardiac cell-to-cell
K. Andelova, T. Egan Beňová, B. Szeiffová Bačová, M. Sýkora, Natalia J Prado, E. Diez, P. Hlivak, N. Tribulova   +7 more
semanticscholar   +1 more source

Acute activation of hemichannels by ethanol leads to Ca2+-dependent gliotransmitter release in astrocytes

Frontiers in Cell and Developmental Biology
Multiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez, Claudia García-Rodríguez, Jesús E. Marillán, Sergio A. Vergara, Tanhia F. Alvear, Arantza Farias-Pasten, Juan C. Sáez, Mauricio A. Retamal, Maximiliano Rovegno, Fernando C. Ortiz, Juan A. Orellana   +10 more
doaj   +1 more source

Connexins in Cancer: Jekyll or Hyde?

Biomolecules, 2020
The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin E. Mulkearns-Hubert, Ofer Reizes, Justin D. Lathia   +2 more
doaj   +1 more source

Analysis of Hemichannels and Gap Junctions: Application and Extension of the Passive Transmembrane Ion Transport Model

Frontiers in Cellular Neuroscience, 2021
Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to form gap junctional channels.
Qiqian Wang, Shenquan Liu
doaj   +1 more source

Nature of plasmalemmal functional “hemichannels”

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
The molecular identity of the protein forming "hemichannels" at non-junctional membranes is disputed. The family of gap junction proteins, innexins, connexins, and pannexins share several common features, including permeability characteristics and sensitivity to blocking agents.
openaire   +2 more sources

Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

Frontiers in Cellular Neuroscience, 2014
Nicotine, the most important neuroteratogen of tobacco smoke, can reproduce brain and cognitive disturbances per se when administered prenatally. However, it is still unknown if paracrine signaling among brain cells participates in prenatal nicotine ...
Juan Andrés Orellana, Dolores eBusso, Gigliola eRamirez, Marlys eCampos, Attilio eRigotti, Jaime eEugenin, Rommy eVon Bernhardi   +6 more
doaj   +1 more source

Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation

Biomolecules, 2020
Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial tissue. Diseases across a wide range of tissue types involve dynamic changes in transcellular junctional complexes and the actin cytoskeleton in the regulation of ...
Randy E. Strauss, Robert G. Gourdie
doaj   +1 more source

S-nitrosylation of Connexin43 hemichannels elicits cardiac stress induced arrhythmias in Duchenne Muscular Dystrophy mice.

JCI Insight, 2019
Patients with Duchene Muscular Dystrophy (DMD) commonly present severe ventricular arrhythmias that contribute to heart failure. Arrhythmias and lethality are also consistently observed in adult Dmdmdx mice, a mouse model of DMD, after acute β-adrenergic
Mauricio A. Lillo, Eric Himelman, N. Shirokova, Lai-Hua Xie, D. Fraidenraich, J. Contreras   +5 more
semanticscholar   +1 more source

Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice

International Journal of Molecular Sciences, 2020
Duchenne muscular dystrophy (DMD) is a fatal disease that causes cardiomyopathy and is associated with oxidative stress. In the heart, oxidative stress interferes with the location of connexin 43 (Cx43) to the intercalated discs causing its ...
Alejandra Z. Vielma, M. Boric, D. González   +2 more
semanticscholar   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source