Results 11 to 20 of about 15,174 (240)

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments

The Journal of Clinical Investigation, 2023
Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert, Maarten A.J. De Smet, Alessio Lissoni, Rosalie Allewaert, H. Llewelyn Roderick, Geert Bultynck, Mario Delmar, Karin R. Sipido, Katja Witschas   +8 more
doaj   +2 more sources

SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics

Biological Research, 2023
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection ...
Juan Prieto-Villalobos, Claudia M. Lucero, Maximiliano Rovegno, Gonzalo I. Gómez, Mauricio A. Retamal, Juan A. Orellana   +5 more
doaj   +2 more sources

Calcium Regulation of Connexin Hemichannels

International Journal of Molecular Sciences
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are of paramount importance for intercellular communication. In physiological conditions, HCs can form gap junction (GJ) channels, providing a direct diffusive path between ...
Erva Bayraktar, Diego Lopez-Pigozzi, Mario Bortolozzi   +2 more
semanticscholar   +4 more sources

Possible role of hemichannels in cancer. [PDF]

Frontiers in Physiology, 2014
In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors.
Kurt Alex Schalper, Kurt Alex Schalper, Daniel Eduardo Carvajal-Hausdorf, Mauricio P. Oyarzo   +3 more
doaj   +3 more sources

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Biological Research
Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana   +12 more
doaj   +2 more sources

Connexin 43 hemichannels and related diseases. [PDF]

Antib Ther
Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels.
Zhang Y, Acosta FM, Jiang JX.
europepmc   +4 more sources

Connexin hemichannels in the lens [PDF]

Frontiers in Physiology, 2014
The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50).
Eric C Beyer, Viviana M. Berthoud
doaj   +3 more sources

Diseases associated with leaky hemichannels.

Frontiers in Cellular Neuroscience, 2015
Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication.
Mauricio Antonio Retamal, Edison Pablo Reyes, Isaac E Garcia, Bernardo ePinto, Agustin Demetrio Martinez, Carlos eGonzalez   +5 more
doaj   +3 more sources

Induction of Connexin-hemichannel Opening

Bio-Protocol, 2014
Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj   +3 more sources

Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3)

Frontiers in Physiology, 2020
Connexin (Cx) proteins form gap junction channels (GJC) and hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space, respectively.
Vania A. Figueroa, Vania A. Figueroa, Oscar Jara, Carolina A. Oliva, Marcelo Ezquer, Fernando Ezquer, Mauricio A. Retamal, Mauricio A. Retamal, Mauricio A. Retamal, Agustín D. Martínez, Guillermo A. Altenberg, Guillermo A. Altenberg, Aníbal A. Vargas, Aníbal A. Vargas   +13 more
doaj   +2 more sources