Results 21 to 30 of about 15,174 (240)

Hemichannels: new roles in astroglial function [PDF]

Frontiers in Physiology, 2014
The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
doaj   +4 more sources

GJB6 missense variant in a Labrador Retriever with paw pad hyperkeratosis. [PDF]

Anim Genet
Abstract Palmoplantar keratoderma in humans is a condition defined by an abnormally thickened cornified skin layer on the hands and feet. In animals, the corresponding disease is commonly termed paw pad hyperkeratosis. It can be acquired due to repeated trauma, infections, cancer, or inflammatory dermatoses, or inherited due to pathogenic variants in ...
Rietmann SJ, Malatos J, Jagannathan V, Leeb T.   +3 more
europepmc   +2 more sources

Co-exposure to cadmium and microplastics promotes liver fibrosis through the hemichannels -ATP-P2X7 pathway.

Chemosphere, 2023
Microplastics (MPs) and cadmium (Cd) are important environmental pollutants, that damage the liver. However, the effect and mechanism of combined Cd and MPs exposure on liver fibrosis are still largely unknown.
Jian Sun, Huayi Qu, Waseem Ali, Yan Chen, Tao Wang, Yonggang Ma, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, H. Zou   +10 more
semanticscholar   +1 more source

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury

Cell Communication and Signaling, 2023
Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
E. Roger, C. Chadjichristos, Panagiotis Kavvadas, Gareth W. Price, C. L. Cliff, S. Hadjadj, Jessy Renciot, P. Squires, C. Hills   +8 more
semanticscholar   +1 more source

Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias

The Journal of General Physiology, 2023
This work demonstrates that the opening of lateralize cardiac connexin-43 hemichannels, in the absence of a cardiac pathology, is still sufficient to alter cardiac membrane excitability and promote arrhythmias upon β-adrenergic cardiac stress.
Mauricio A. Lillo, Manuel F. Muñoz, P. Rhana, Kelli Gaul-Muller, Jonathan J. Quan, N. Shirokova, Lai-Hua Xie, L. F. Santana, D. Fraidenraich, J. Contreras   +9 more
semanticscholar   +1 more source

Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Although symptomatic medications are available, many temporal lobe epilepsy (TLE) patients remain unresponsive to treatment and new drug targets are needed. Connexin-based gap junctions and hemichannels in brain glial cells are implicated in
Anni Guo, Huiqi Zhang, Huanhuan Li, Arthur N. L. Chiu, Claudia García-Rodríguez, C. Lagos, J. Sáez, C. G. Lau   +7 more
semanticscholar   +1 more source

Opening of Cx43-formed hemichannels mediates the Ca2+ signaling associated with endothelial cell migration

Biology Direct, 2023
Endothelial cell migration is a key process in angiogenesis. Progress of endothelial cell migration is orchestrated by coordinated generation of Ca^2+ signals through a mechanism organized in caveolar microdomains.
H. Espinoza, X. Figueroa
semanticscholar   +1 more source

Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Our results demonstrate that connexin 43 hemichannels are the conduits for amyotrophic lateral sclerosis (ALS) astrocyte-mediated motor neuron toxicity and disease spread, acting as a common mechanism that can target both familial ALS and ...
Akshata A Almad, Arens Taga, J. Joseph, Sarah K Gross, Connor Welsh, Aneesh Patankar, Jean-Philippe Richard, Khalil Rust, Aayush Pokharel, Caroline F. Plott, Mauricio A. Lillo, Raha M. Dastgheyb, K. Eggan, N. Haughey, J. Contreras, N. Maragakis   +15 more
semanticscholar   +1 more source

Following Tracks of Hemichannels [PDF]

Cell Communication & Adhesion, 2003
It has been suggested that plasma membrane-bound hemichannels perform physiological and pathophysiological functions per se. Such functions require the presence of hemichannels on the cell surface and their accessibility to the extracellular environment for at least some limited period of time.
Rolf, Dermietzel, Carola, Meier, Feliksas, Bukauskas, David C, Spray   +3 more
openaire   +3 more sources

The Role of Connexin Hemichannels in Inflammatory Diseases

Biology, 2022
Simple Summary Connexin hemichannels are formed by connexin protein family members, and connect cytosol and extracellular milium. The function of connexin hemichannels cannot be readily distinguished from the gap junctions formed also by connexins, or ...
Bo Peng, Chengping Xu, Shuaiwei Wang, Yijie Zhang, Wei Li   +4 more
semanticscholar   +1 more source