Results 31 to 40 of about 15,174 (240)
bioRxiv, 2022 Oxidative stress is a major risk factor that causes osteocyte cell death and bone loss. Prior studies primarily focus on the function of cell surface expressed Cx43 channels.
Jingruo Zhang +5 more
semanticscholar +1 more source
Hunting for connexin hemichannels [PDF]
FEBS Letters, 2014 Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research. Defining functions of hemichannels and their involvement in any biological event requires ruling out possible participation of other channels that share biophysical and regulatory properties,
Saez, Juan C., Leybaert, Luc
openaire +4 more sources
Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells
Bio-Protocol, 2021 Connexins are membrane bound proteins that facilitate direct and local paracrine mediated cell-to-cell communication through their ability to oligomerise into hexameric hemichannels.
Joe Potter +5 more
doaj +1 more source
Bone Research, 2021 Mechanical loading opens connexin 43 (Cx43) hemichannels (HCs), leading to the release of bone anabolic molecules, such as prostaglandins, from mechanosensitive osteocytes, which is essential for bone formation and remodeling.
M. Riquelme +3 more
semanticscholar +1 more source
Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons
International Journal of Molecular Sciences, 2022 Hypertension is one of the most common risk factors for developing chronic cardiovascular diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes damage and activation of mesangial cells (MCs), eliciting the production of
Claudia M. Lucero +9 more
semanticscholar +1 more source
GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels
International Journal of Molecular Sciences, 2022 Gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. It is produced by interneurons and recycled by astrocytes. In neurons, GABA activates the influx of Cl- via the GABAA receptor or efflux or K+ via the GABAB receptor,
Ivanka Jiménez-Dinamarca +10 more
semanticscholar +1 more source
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading
eLife, 2022 Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao +6 more
doaj +1 more source
Adhesive properties of connexin hemichannels [PDF]
Glia, 2008 AbstractGap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecules and other signaling elements.
M L, Cotrina, J H-C, Lin, M, Nedergaard
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Hemichannel-mediated release of lactate [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2015 In the central nervous system lactate contributes to the extracellular pool of readily available energy substrates and may also function as a signaling molecule which mediates communication between glial cells and neurons. Monocarboxylate transporters are believed to provide the main pathway for lactate transport across the membranes.
Karagiannis, Anastassios +5 more
openaire +6 more sources
Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria
Molecules, 2017 In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling ...
Mariana C. Fiori +4 more
doaj +1 more source