Results 51 to 60 of about 15,174 (240)
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system [PDF]
, 2012 ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Bultynck, Geert +7 more
core +3 more sources
Cryopreservation of equine oocytes: looking into the crystal ball [PDF]
, 2020 In vitro embryo production has evolved rapidly in the horse over the past decade, but blastocyst rates from vitrified equine oocytes remain quite poor and further research is needed to warrant application.
Angel Velez, Daniel +4 more
core +2 more sources
Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
core +2 more sources
Mechanisms Underlying Connexin Hemichannel Activation in Disease [PDF]
International Journal of Molecular Sciences, 2021 Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease.
Raf Van Campenhout +5 more
openaire +3 more sources
Harnessing the Therapeutic Potential of Antibodies Targeting Connexin Hemichannels.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021 BACKGROUND Connexin hemichannels have been implicated in pathology-promoting conditions, including inflammation, numerous widespread human diseases, including cancer and diabetes, and several rare diseases linked to pathological point mutations ...
D. Buratto +3 more
semanticscholar +1 more source
Biomolecules, 2023 Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation
Yuting Li +2 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 Maternal inflammation during pregnancy causes later-in-life alterations of the offspring’s brain structure and function. These abnormalities increase the risk of developing several psychiatric and neurological disorders, including schizophrenia ...
Juan Prieto-Villalobos +9 more
semanticscholar +1 more source
Connexin hemichannels and cell-cell channels: comparison of properties
Brazilian Journal of Medical and Biological Research, 2000 Connexin46 (Cx46) forms functional hemichannels in the absence of contact by an apposed hemichannel and we have used these hemichannels to study gating and permeation at the single channel level with high time resolution.
V.K. Verselis +2 more
doaj +1 more source
Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity? [PDF]
, 2017 Indexación: Scopus.In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons.
Alcayaga, J. +3 more
core +1 more source
Frontiers in Neurology, 2020 Ischemic stroke is a multi-factorial cerebrovascular disease with high worldwide morbidity and mortality. In the past few years, multiple studies have revealed the underlying mechanism of ischemia/reperfusion injury, including calcium overload, amino ...
Zhen Liang +7 more
semanticscholar +1 more source