Results 61 to 70 of about 15,174 (240)
Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids
Science Advances, 2020 Cryo-EM structures of the undocked INX-6 hemichannels reveal a pore obstruction and N-terminal rearrangement in lipids. Gap junctions form intercellular conduits with a large pore size whose closed and open states regulate communication between adjacent ...
B. Burendei +6 more
semanticscholar +1 more source
Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. [PDF]
PLoS ONE, 2013 Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation.
Pablo J Sáez +9 more
doaj +1 more source
Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
doaj +1 more source
Connexin 43 Channels in Osteocytes Regulate Bone Responses to Mechanical Unloading
Frontiers in Physiology, 2020 Connexin (Cx) 43 forms gap junctions and hemichannels that mediate communication between osteocytes and adjacent cells or the extracellular environment in bone, respectively.
Dezhi Zhao +10 more
doaj +1 more source
What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]
, 2018 Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
core +1 more source
Connexin hemichannels and cochlear function [PDF]
Neuroscience Letters, 2019 Connexins play vital roles in hearing, including promoting cochlear development and sustaining auditory function in the mature cochlea. Mutations in connexins expressed in the cochlear epithelium, Cx26 and Cx30, cause sensorineural deafness and in the case of Cx26, is one of the most common causes of non-syndromic, hereditary deafness.
openaire +2 more sources
Cues to opening mechanisms from in silico electric field excitation of cx26 hemichannel and in vitro mutagenesis studies in HeLa transfectans [PDF]
, 2018 Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Bruno, Francesca +7 more
core +1 more source
Connexin Hemichannels in Astrocytes: Role in CNS Disorders
Frontiers in Molecular Neuroscience, 2019 In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the ...
Lingyan Xing +3 more
semanticscholar +1 more source
Redox Biology, 2016 Connexin (Cx) hemichannels regulate many cellular processes with little information available regarding their mechanisms. Given that many pathological factors that activate hemichannels also disrupts the integrity of cellular junctions, we speculated a ...
Yuan Chi +6 more
doaj +1 more source
Connexins : substrates and regulators of autophagy [PDF]
, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +1 more source