Results 71 to 80 of about 15,174 (240)

Large-pore connexin hemichannels function like molecule transporters independent of ion conduction

Proceedings of the National Academy of Sciences of the United States of America
Significance The mechanism behind molecule permeation through large-pore connexin hemichannels remains enigmatic. The current perspective posits that ions and molecules diffuse simultaneously, with molecule selectivity and permeability mainly relying on ...
P. Gaete, Deepak Kumar, Cynthia I. Fernandez, Juan M Valdez Capuccino, Aashish Bhatt, Wenjuan Jiang, Yi-Chun Lin, Yu Liu, Andrew L. Harris, Y. Luo, Jorge E. Contreras   +10 more
semanticscholar   +1 more source

Differential sensitivity of brainstem vs cortical astrocytes to changes in pH reveals functional regional specialization of astroglia [PDF]

, 2013
Astrocytes might function as brain interoceptors capable of detecting different (chemo)sensory modalities and transmitting sensory information to the relevant neural networks controlling vital functions.
Castaldo, C, Gourine, A, Kasimov, V, Kasparov, Sergey, Larina, O, Marina, N, Patrushev, M   +6 more
core   +2 more sources

Voltage-dependent facilitation of Cx46 hemichannels

American Journal of Physiology-Cell Physiology, 2010
Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane voltage, extracellular divalent ion concentration, phosphorylation, pH, and redox potential ...
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus. [PDF]

, 2015
Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy.
Binder, Devin K, Davila, David, Fiacco, Todd A, Lauderdale, Kelli, Murphy, Thomas, Tung, Tina   +5 more
core   +3 more sources

A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice

EBioMedicine, 2020
Background Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as “leaky” hemichannels.
Y. Kuang, Veronica Zorzi, D. Buratto, G. Ziraldo, F. Mazzarda, Chiara Peres, C. Nardin, A. Salvatore, Francesco Chiani, F. Scavizzi, M. Raspa, Min Qiang, Youjun Chu, Xiaojie Shi, Yu Li, Lili Liu, Yaru Shi, F. Zonta, Guang Yang, R. Lerner, F. Mammano   +20 more
semanticscholar   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Connexin hemichannels: novel mediators of toxicity [PDF]

Archives of Toxicology, 2014
Tissue homeostasis is driven by a myriad of extracellular, intracellular and intercellular signaling networks. Direct communication between neighboring cells is typically controlled by gap junctions (Decrock et al. 2009; Nielsen et al. 2012; Vinken et al. 2011).
openaire   +3 more sources

Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases

Frontiers in Physiology, 2014
In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez, Stephani eVelasquez, Eliseo A Eugenin, Eliseo A Eugenin   +3 more
doaj   +1 more source

Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. [PDF]

PLoS ONE, 2012
Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive.
Jingwei Chi, Li Li, Mujun Liu, Jieqiong Tan, Chengyuan Tang, Qian Pan, Danling Wang, Zhuohua Zhang   +7 more
doaj   +1 more source