Results 81 to 90 of about 15,174 (240)

Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity

Frontiers in Neuroscience, 2022
Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation, a proinflammatory environment and the generation of reactive oxygen species ...
Sofia Waissbluth, Juan Cristóbal Maass, Helmuth A. Sanchez, Agustín D. Martínez   +3 more
doaj   +1 more source

Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea [PDF]

, 2017
open9siMutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans.

core   +1 more source

Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels

Journal of Cell Biology, 2020
Khalil et al. show that breast cancer cells release purines into the extracellular space via connexin-43 hemichannels. Extracellular purines activate adenosine receptors and the AKT pathway to induce and maintain leader cell function and collective ...
Antoine A. Khalil, Olga V. Ilina, A. Vasaturo, Jan-Hendrik Venhuizen, Manon Vullings, Victor Venhuizen, A. Bilos, C. Figdor, P. Span, P. Friedl   +9 more
semanticscholar   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

Molecular basis of gap junctional communication in the CNS of the leech Hirudo medicinalis [PDF]

, 2004
Gap junctions are intercellular channels that allow the passage of ions and small molecules between cells. In the nervous system, gap junctions mediate electrical coupling between neurons.
Bacon, Jonathan P, Davies, Jane A, Dykes, Iain M, Freeman, Fiona M   +3 more
core   +3 more sources

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels

Pharmaceuticals, 2020
Recent studies using the genetic partial epilepsy model have demonstrated that hyperfunction of astroglial hemichannels contributes to pathomechanism of epileptic seizure.
K. Fukuyama, Y. Ueda, M. Okada
semanticscholar   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, EarlyView.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Connexons and pannexons: newcomers in neurophysiology

Frontiers in Cellular Neuroscience, 2014
Connexin hemichannels are single membrane channels which have been traditionally thought to work in pairs to form gap junction channels across two opposing cells.
Giselle eCheung, Oana eChever, Nathalie eRouach   +2 more
doaj   +1 more source

Detecting CO2-Sensitive Hemichannels in Neurons in Acute Brain Slices

STAR Protocols, 2020
Summary: This protocol provides two independent methods to functionally detect the neuronal expression of CO2-sensitive hemichannels. These hemichannels (consisting of connexins 26 or 30) are directly gated by CO2, independent of pH changes and until ...
Emily Hill, Nicholas Dale, Mark J. Wall
doaj   +1 more source