Results 1 to 10 of about 81,640 (295)
Heparan sulfates and heparan sulfate binding proteins in sepsis
Frontiers in Molecular Biosciences, 2023 Heparan sulfates (HSs) are the main components in the glycocalyx which covers endothelial cells and modulates vascular homeostasis through interactions with multiple Heparan sulfate binding proteins (HSBPs).
Yi-En Liao, Jian Liu, Katelyn Arnold
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Heparan Sulfate Proteoglycans in Tauopathy
Biomolecules, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu +7 more
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The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer [PDF]
Breast Cancer ResearchBackground Breast cancer, one of the most common forms of cancer, is associated with the highest cancer-related mortality among women worldwide. In comparison to other types of breast cancer, patients diagnosed with the triple-negative breast cancer ...
Jasmine M. Manouchehri +12 more
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Heparin Mimetics and Their Impact on Extracellular Matrix Protein Assemblies
Pharmaceuticals, 2023 Heparan sulfate is a crucial extracellular matrix component that organizes structural features and functional protein processes. This occurs through the formation of protein–heparan sulfate assemblies around cell surfaces, which allow for the deliberate ...
Fabian Heide +2 more
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Biomedicines, 2022 White adipose tissues are major endocrine organs that release factors, termed adipokines, which affect other major organ systems. The development and functions of adipose tissues depend largely upon the glycosaminoglycan heparan sulfate.
J. Michael Sorrell, Arnold I. Caplan
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Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage
Biomedicines, 2020 Heparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate plays an important role in neutralizing the activities of proinflammatory
Katelyn Arnold, Yi-En Liao, Jian Liu
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MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides
Frontiers in Immunology, 2020 It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma +15 more
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Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery.
PLoS ONE, 2021 BackgroundExperimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate.
Arie Passov +5 more
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Heparan sulfate is a plasma biomarker of acute cellular allograft rejection. [PDF]
PLoS ONE, 2018 Despite advances in management of immunosuppression, graft rejection remains a significant clinical problem in solid organ transplantation. Non-invasive biomarkers of graft rejection can facilitate earlier diagnosis and treatment of acute rejection.
Andrew S Barbas +6 more
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Frontiers in Immunology, 2017 Thoracoabdominal aortic aneurysm (TAAA) is a highly lethal disorder requiring open or endovascular TAAA repair, both of which are rare, but extensive and complex surgical procedures associated with a significant systemic inflammatory response and high ...
Lukas Martin +11 more
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