Results 91 to 100 of about 465,990 (261)

A unique role for 6-O sulfation modification in zebrafish vascular development [PDF]

, 2005
Heparan sulfate proteoglycans are important modulators of growth factor signaling in a variety of patterning processes. Secreted growth factors that play critical roles in angiogenesis bind to heparan sulfate, and this association is affected by 6-O ...
Chen, Eleanor, Ekker, Stephen C., Rusch, Melissa A., Selleck, Scott B., Stringer, Sally E.   +4 more
core   +1 more source

Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

Critical Care, 2019
Background Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury.
Joseph A. Hippensteel, Ryo Uchimido, Patrick D. Tyler, Ryan C. Burke, Xiaorui Han, Fuming Zhang, Sarah A. McMurtry, James F. Colbert, Christopher J. Lindsell, Derek C. Angus, John A. Kellum, Donald M. Yealy, Robert J. Linhardt, Nathan I. Shapiro, Eric P. Schmidt   +14 more
doaj   +1 more source

The Affinity of the Sulfate- and Ether-Containing Surface-Active Ionic Liquids to Carbon Dioxide, Hydrogen Fluoride, Hydrogen Sulfide, and Water [PDF]

arXiv, 2022
The development of novel task-specific ionic liquids (ILs) represents an essential challenge in modern organic and physical chemistries. Recently we reported surface-active ILs contained the two well-known organic cations (1-butyl-3-methylimidazolium and tetrabutylammonium) and the two surface-active anions (lauryl sulfate, lauryl ether sulfate).
arxiv  

Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids.

American Journal of Physiology. Heart and Circulatory Physiology, 2016
The endothelial glycocalyx plays an essential role in many physiological functions and is damaged after hemorrhage. Fluid resuscitation may further change the glycocalyx after an initial hemorrhage-induced degradation.
I. T. Torres Filho, L. Torres, C. Salgado, M. Dubick   +3 more
semanticscholar   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling [PDF]

, 2016
The relative roles of SULF1 and SULF2 enzymes in tumour growth are controversial, but short SULF1/SULF2 splice variants predominate in human mammary tumours despite their non-detectable levels in normal mammary tissue. Compared with the normal, the level
Dhoot, G K, Gill, R M S, Mehra, V, Milford, E   +3 more
core   +1 more source

Synthesis of 3-O-Sulfated Oligosaccharides to Understand the Relationship between Structures and Functions of Heparan Sulfate.

Journal of the American Chemical Society, 2017
The sulfation at the 3-OH position of glucosamine is an important modification in forming structural domains for heparan sulfate to enable its biological functions.
Zhangjie Wang, Po-Hung Hsieh, Yongmei Xu, David F. Thieker, Evangeline Juan En Chai, Shaoshuai Xie, B. Cooley, R. Woods, Lianli Chi, Jian Liu   +9 more
semanticscholar   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Cell-to-cell transmission of p53 aggregates: a novel player in oncology?

Molecular & Cellular Oncology, 2021
The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear.
Naoyuki Iwahashi, Midori Ikezaki, Hiroyuki Saito, Kenji Uchimura, Kazuchika Nishitsuji   +4 more
doaj   +1 more source

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source