Results 161 to 170 of about 81,640 (295)

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink   +4 more
wiley   +1 more source

Osteochondrosis in horses: An overview of genetic and other factors

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez   +2 more
wiley   +1 more source

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

open access: yesThe FEBS Journal, EarlyView.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert   +16 more
wiley   +1 more source

Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro

open access: yesThe FEBS Journal, EarlyView.
Interactions between bacteria and the extracellular matrix are a prerequisite for colonisation and infection. Phylogenetically diverse M proteins of group A Streptococcus (GAS) can selectively bind sulfated glycosaminoglycans with high affinity. M protein‐mediated recruitment of chondroitin sulfate and dermatan sulfate was shown to increase GAS ...
Tahnee B.‐D. McEwan   +8 more
wiley   +1 more source

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

open access: yesThe FEBS Journal, EarlyView.
Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou   +6 more
wiley   +1 more source

Effectiveness and safety of antithrombin for treatment of portal vein thrombosis: Nationwide prospective surveillance of 4 years of clinical experience in Japan

open access: yesHepatology Research, EarlyView.
Abstract Aim Antithrombin (AT), a plasma protein with anticoagulant properties, has a long‐standing medical history, primarily for treatment of congenital AT deficiency. Accumulated clinical experiences suggest AT is a potential anticoagulant for thrombotic diseases. This study aimed to clarify the effectiveness, safety, and clinical significance of AT
Shoichi Matsutani   +2 more
wiley   +1 more source

Interaction of aminoglycosides with heparan sulfate from rat kidney.

open access: bronze, 1987
Yukihiko Aramaki   +3 more
openalex   +2 more sources

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