Results 11 to 20 of about 81,640 (295)

Heparan sulfate and cell division [PDF]

Brazilian Journal of Medical and Biological Research, 1999
Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic ...
Porcionatto M.A., Nader H.B., Dietrich C.P.   +2 more
doaj   +10 more sources

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]

Frontiers in Endocrinology, 2018
Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan, Parmanand Malvi, Narendra Wajapeyee, Narendra Wajapeyee   +3 more
doaj   +4 more sources

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type [PDF]

Scientific Reports, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse, Hodaka Yamakado, Xander M. van Wijk, Roger Lawrence, Jeffrey D. Esko, Eliezer Masliah   +5 more
doaj   +3 more sources

Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]

Brazilian Journal of Medical and Biological Research, 2006
The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
C.C. Lopes, C.P. Dietrich, H.B. Nader
doaj   +3 more sources

Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. [PDF]

, 2011
Sanfilippo syndrome type B (MPS IIIB) is characterized by profound mental retardation in childhood, dementia and death in late adolescence; it is caused by deficiency of α-N-acetylglucosaminidase and resulting lysosomal storage of heparan sulfate.
Neufeld, Elizabeth F, Ohmi, Kazuhiro, Zhao, Hui-Zhi   +2 more
core   +10 more sources

Heparan Sulfate Proteoglycans [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Jeffrey D. Esko, Stéphane Sarrazin, William C. Lamanna   +2 more
openaire   +2 more sources

Roles of Heparan Sulfate Sulfation in Dentinogenesis [PDF]

Journal of Biological Chemistry, 2012
Cell surface heparan sulfate (HS) is an essential regulator of cell signaling and development. HS traps signaling molecules, like Wnt in the glycosaminoglycan side chains of HS proteoglycans (HSPGs), and regulates their functions. Endosulfatases Sulf1 and Sulf2 are secreted at the cell surface to selectively remove 6-O-sulfate groups from HSPGs ...
Hayano, S., Kurosaka, H., Yanagita, T., Kalus, Ina, Milz, Fabian, Ishihara, Y., Nururu, M. N., Kawanabe, N., Saito, M., Kamioka, H., Adachi, T., Dierks, Thomas, Yamashiro, T.   +12 more
openaire   +4 more sources

Heparan sulfate proteoglycans and cancer [PDF]

British Journal of Cancer, 2001
Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached.
Blackhall, F. H., Merry, C. L R, Davies, E. J., Jayson, G. C.   +3 more
openaire   +2 more sources

Interactions of proteins with heparan sulfate. [PDF]

Essays Biochem
Abstract Heparan sulfate (HS) is a glycosaminoglycan, polysaccharides that are considered to have arisen in the last common unicellular ancestor of multicellular animals. In this light, the large interactome of HS and its myriad functions in relation to the regulation of cell communication are not surprising.
Alotaibi FS, Alsadun MMR, Alsaiari SA, Ramakrishnan K, Yates EA, Fernig DG.   +5 more
europepmc   +3 more sources

Molecular diversity of heparan sulfate [PDF]

Journal of Clinical Investigation, 2001
Heparan sulfate (HS) appeared early in metazoan evolution. As such, many of the structural motifs (variably sulfated disaccharide subunits) that characterize HS (and heparin) were established early on and have been preserved in modern organisms. Thus, many of the biological functions associated with HS either occurred early in evolution or have ...
Jeffrey D. Esko, Ulf Lindahl
openaire   +3 more sources