Results 11 to 20 of about 84,900 (313)
Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]
Frontiers in Endocrinology, 2018 Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan +3 more
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Interactions of proteins with heparan sulfate. [PDF]
Essays BiochemAbstract Heparan sulfate (HS) is a glycosaminoglycan, polysaccharides that are considered to have arisen in the last common unicellular ancestor of multicellular animals. In this light, the large interactome of HS and its myriad functions in relation to the regulation of cell communication are not surprising.
Alotaibi FS +5 more
europepmc +3 more sources
Heparan Sulfate Proteoglycans [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Jeffrey D. Esko +2 more
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Roles of Heparan Sulfate Sulfation in Dentinogenesis [PDF]
Journal of Biological Chemistry, 2012 Cell surface heparan sulfate (HS) is an essential regulator of cell signaling and development. HS traps signaling molecules, like Wnt in the glycosaminoglycan side chains of HS proteoglycans (HSPGs), and regulates their functions. Endosulfatases Sulf1 and Sulf2 are secreted at the cell surface to selectively remove 6-O-sulfate groups from HSPGs ...
Hayano, S. +12 more
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MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides
Frontiers in Immunology, 2020 It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma +15 more
doaj +1 more source
Heparan sulfate proteoglycans and cancer [PDF]
British Journal of Cancer, 2001 Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached.
Blackhall, F. H. +3 more
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Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides [PDF]
, 2020 Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date.
Grabarics, Márkó +9 more
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Matrix Biology Plus, 2022 The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius +4 more
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Molecular diversity of heparan sulfate [PDF]
Journal of Clinical Investigation, 2001 Heparan sulfate (HS) appeared early in metazoan evolution. As such, many of the structural motifs (variably sulfated disaccharide subunits) that characterize HS (and heparin) were established early on and have been preserved in modern organisms. Thus, many of the biological functions associated with HS either occurred early in evolution or have ...
Jeffrey D. Esko, Ulf Lindahl
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Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery.
PLoS ONE, 2021 BackgroundExperimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate.
Arie Passov +5 more
doaj +1 more source