Results 11 to 20 of about 465,990 (261)

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]

Scientific Reports, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D, Ihse, Elisabet, Lawrence, Roger, Masliah, Eliezer, van Wijk, Xander M, Yamakado, Hodaka   +5 more
core   +4 more sources

Heparan sulfates and heparan sulfate binding proteins in sepsis

Frontiers in Molecular Biosciences, 2023
Heparan sulfates (HSs) are the main components in the glycocalyx which covers endothelial cells and modulates vascular homeostasis through interactions with multiple Heparan sulfate binding proteins (HSBPs).
Yi-En Liao, Jian Liu, Katelyn Arnold
doaj   +2 more sources

Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity [PDF]

Infection and Immunity, 2015
Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate ...
Brinkmann, Volker, Chang, Yung-Chi, Cole, Jason N, Esko, Jeffrey D, Nizet, Victor, Olson, Joshua, van Wijk, Xander M, Xu, Ding, Zychlinsky, Arturo   +8 more
core   +2 more sources

Heparan sulfate and cell division [PDF]

Brazilian Journal of Medical and Biological Research, 1999
Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic ...
Dietrich, Carl Peter [UNIFESP], Nader, Helena Bonciani [UNIFESP], Porcionatto, Marimélia Aparecida [UNIFESP]   +2 more
core   +4 more sources

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression

Frontiers in Endocrinology, 2018
Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan, Parmanand Malvi, Narendra Wajapeyee, Narendra Wajapeyee   +3 more
doaj   +2 more sources

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity

Molecules, 2020
Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are specifically modified by the addition of heparan sulfate, a linear polysaccharide from the ...
Thibault Annaval, Rebekka Wild, Yoann Crétinon, Rabia Sadir, Romain R. Vivès, Hugues Lortat-Jacob   +5 more
doaj   +2 more sources

Heparan Sulfate-Dependent Enhancement of Henipavirus Infection

mBio, 2015
Nipah virus and Hendra virus are emerging, highly pathogenic, zoonotic paramyxoviruses that belong to the genus Henipavirus. They infect humans as well as numerous mammalian species.
Cyrille Mathieu, Kévin P. Dhondt, Marie Châlons, Stéphane Mély, Hervé Raoul, Didier Negre, François-Loïc Cosset, Denis Gerlier, Romain R. Vivès, Branka Horvat   +9 more
doaj   +2 more sources

Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]

Brazilian Journal of Medical and Biological Research, 2006
The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
Dietrich, Carl Peter, Lopes, Carla Cristina, Nader, Helena Bonciani   +2 more
core   +4 more sources

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

bioRxiv, 2020
We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain.
T. M. Clausen, Daniel R Sandoval, Charlotte Spliid, Jessica Pihl, Chelsea D Painter, Bryan E. Thacker, C. Glass, Anoop Narayanan, Sydney A. Majowicz, Yang Zhang, J. Torres, Gregory J. Golden, Ryan N Porell, Aaron F. Garretson, Logan K. Laubach, J. Feldman, Xin Yin, Yuan Pu, B. Hauser, T. Caradonna, Benjamin P. Kellman, C. Martino, P. Gordts, S. Leibel, Summit K. Chanda, A. Schmidt, K. Godula, J. Jose, K. Corbett, A. Ward, A. Carlin, J. Esko   +31 more
semanticscholar   +2 more sources

Heparan Sulfate Proteoglycans in Tauopathy

Biomolecules, 2022
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu, Lauren Gandy, Fuming Zhang, Jian Liu, Chunyu Wang, Laura J. Blair, Robert J. Linhardt, Lianchun Wang   +7 more
doaj   +1 more source