Results 191 to 200 of about 84,900 (313)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, Volume 599, Issue 19, Page 2718-2749, October 2025.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils. [PDF]

Commun Biol
Vanderperre B, Muraleedharan A, Dorion MF, Larroquette F, Del Cid Pellitero E, Rajakulendran N, Chen CX, Larivière R, Michaud-Tardif C, Goiran T, Chidiac R, Lipuma D, MacLeod G, Thomas R, Wang Z, Reintsch WE, Luo W, Shlaifer I, Zhang F, Xia K, Steinhart Z, Linhardt RJ, Trempe JF, Liu J, Durcan TM, Angers S, Fon EA.   +26 more
europepmc   +1 more source

Biosynthesis of Heparin and Heparan Sulfate [PDF]

Upsala Journal of Medical Sciences, 1977
openaire   +3 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, Volume 15, Issue 10, Page 1552-1569, October 2025.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.

, 1991
Douglas M. Noonan, Anna Fulle, Piera Valente, Silla Cai, Elizabeth A. Horigan, Makoto Sasaki, Yasuhiro Yamada, John R. Hassell   +7 more
openalex   +1 more source

Heparan sulfate chains in hepatocellular carcinoma. [PDF]

Gastroenterol Rep (Oxf)
Guyot E.
europepmc   +1 more source

Optimized Cell‐Based Platform for Platelet‐Free Detection of Heparin‐Induced Thrombocytopenia Antibodies

Advanced Biology, Volume 9, Issue 10, October 2025.
This study optimized a cell‐based ELISA for HIT antibody detection using PF4‐coated breast cancer cells (MDA‐MB‐231). Enhanced binding was observed at 50 mM NaCl and 4% paraformaldehyde fixation. Live MDA‐MB‐231 and HCT‐116 cells demontrated superior sensitivity and specificity, providing a promising platelet‐free alternative for clinical HIT diagnosis.
Li‐Yu Chen, Uwe Schirmer, Peter F. Zipfel, Doris Heinrich, Thi‐Huong Nguyen   +4 more
wiley   +1 more source

Applications of Surface Plasmon Resonance in Heparan Sulfate Interactome Research. [PDF]

Biomedicines
Datta P, Dordick JS, Zhang F.
europepmc   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, Volume 37, Issue 40, October 9, 2025.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

[Chemical studies on chondroitin sulfate and heparan sulfate peptides from human aorta. IV].

, 1969
Almuth Klemer, D. Mempel, K. Römer
openalex